Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis · 1999
Recurrent infection and catheter loss in patients on continuous ambulatory peritoneal dialysis.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Bayston R, Andrews M, Rigg K, Shelton A
Аннотация
OBJECTIVE: To elucidate the factors leading to catheter loss from recurrent infection in patients on continuous ambulatory peritoneal dialysis (CAPD).
DESIGN: All catheters removed from patients were prospectively examined for infection.
SETTING: CAPD unit in large tertiary-care general hospital.
PATIENTS: Sixty-five consecutive patients undergoing catheter removal for whatever cause; 20 catheters rejected because of desiccation or contamination in transit.
INTERVENTIONS: None.
MAIN OUTCOME MEASURES: Micro-organisms linked to catheter removal; their locations on removed catheters.
RESULTS: Of 45 catheters removed between January 1994 and August 1995, 26 were infected: 13/26 infections were caused by Staphylococcus aureus and 7/26 by Pseudomonas aeruginosa. In only one case was S. epidermidis associated with catheter removal. The most striking finding was that the inner cuff harbored large numbers of the infecting organisms, even when antibiotics had eradicated them from the peritoneal cavity and exit site, where present, and the catheter lumen.
CONCLUSION: The importance of S. aureus and Ps. aeruginosa rather than S. epidermidis in catheter loss due to relapsing infection is confirmed. Persistence of the causative organisms in the inner cuff is a likely explanation for relapse after treatment, and might be due to the predominantly intraperitoneal administration of antibiotics. A clinical trial of the effect on catheter retention of empirical use of systemic or oral agents that give high tissue levels and are active against intracellular micro-organisms, along with recommended intraperitoneal regimens, is indicated.
DESIGN: All catheters removed from patients were prospectively examined for infection.
SETTING: CAPD unit in large tertiary-care general hospital.
PATIENTS: Sixty-five consecutive patients undergoing catheter removal for whatever cause; 20 catheters rejected because of desiccation or contamination in transit.
INTERVENTIONS: None.
MAIN OUTCOME MEASURES: Micro-organisms linked to catheter removal; their locations on removed catheters.
RESULTS: Of 45 catheters removed between January 1994 and August 1995, 26 were infected: 13/26 infections were caused by Staphylococcus aureus and 7/26 by Pseudomonas aeruginosa. In only one case was S. epidermidis associated with catheter removal. The most striking finding was that the inner cuff harbored large numbers of the infecting organisms, even when antibiotics had eradicated them from the peritoneal cavity and exit site, where present, and the catheter lumen.
CONCLUSION: The importance of S. aureus and Ps. aeruginosa rather than S. epidermidis in catheter loss due to relapsing infection is confirmed. Persistence of the causative organisms in the inner cuff is a likely explanation for relapse after treatment, and might be due to the predominantly intraperitoneal administration of antibiotics. A clinical trial of the effect on catheter retention of empirical use of systemic or oral agents that give high tissue levels and are active against intracellular micro-organisms, along with recommended intraperitoneal regimens, is indicated.
Предметные рубрики MeSH
Administration, OralAnti-Bacterial AgentsBacterial InfectionsCatheters, IndwellingHumansInjections, IntraperitonealPeritoneal CavityPeritoneal Dialysis, Continuous AmbulatoryProspective StudiesPseudomonas InfectionsPseudomonas aeruginosaRecurrenceStaphylococcal InfectionsStaphylococcus aureusStaphylococcus epidermidisTissue Distribution