Navigating regulatory fragmentation in the convergence of synthetic biology, artificial intelligence, and automation.

The convergence of synthetic biology, artificial intelligence (AI), and automation (SynBioxAI) creates research activities that simultaneously engage biosecurity, AI governance, export control, and data sovereignty frameworks - none of which are designed for convergent science. We conduct a comprehensive cross-jurisdictional analysis of this regulatory landscape across sixteen nations, identifying critical ambiguities where novel SynBioxAI objects fall between established regulatory categories. Through seven realistic collaboration scenarios, we demonstrate that regulatory friction is multiplicative rather than additive. We propose the SynBioxAI Regulatory Interoperability Toolkit (RIOT): a practical, seven-lens institutional framework that gives research institutions the capacity to navigate regulatory divergence efficiently and transparently.