Quantitative Cardiac MRI in COVID-19 Vaccine-Related Versus Other Types of Myocarditis: A Korean Multicenter Study.
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Cannarella Rossella, Shah Rupin, Hamoda Taha Abo-Almagd Abdel-Meguid, Boitrelle Florence, Saleh Ramadan, Gul Murat, Rambhatla Amarnath, Kavoussi Parviz, Toprak Tuncay, Harraz Ahmed M, Ko Edmund, Çeker Gökhan, Durairajanayagam Damayanthi, Alkahidi Noora, Kuroda Shinnosuke, Crafa Andrea, Henkel Ralf, Salvio Gianmaria, Hazir Berk, Darbandi Mahsa, Bendayan Marion, Darbandi Sara, Falcone Marco, Garrido Nicolas, Kosgi Raghavender, Sawaid Kaiyal Raneen, Karna Keshab, Phuoc Nguyen Ho Vinh, Birowo Ponco, Colpi Giovanni M, de la Rosette Jean, Pinggera Germar-Michael, Nguyen Quang, Zini Armand, Zohdy Wael, Singh Rajender, Saini Pallavi, Glina Sidney, Lin Haocheng, Mostafa Taymour, Rojas-Cruz Cesar, Arafa Mohamed, Calogero Aldo E, Dimitriadis Fotios, Kothari Priyank, Karthikeyan Vilvapathy Senguttuvan, Okada Keisuke, Chiba Koji, Kadıoglu Ates, Altay Baris, Turunc Tahsin, Zilaitiene Birute, Gokalp Fatih, Adamyan Aram, Katz Darren, Chung Eric, Mierzwa Tiago Cesar, Zylbersztejn Daniel Suslik, Paul Gustavo Marquesine, Sofikitis Nikolaos, Sokolakis Ioannis, Malhotra Vineet, Brodjonegoro Sakti Ronggowardhana, Adriansjah Ricky, Tsujimura Akira, Amano Toshiyasu, Balercia Giancarlo, Ziouziou Imad, Deswanto Isaac Ardianson, Martinez Marlon, Park Hyun Jun, Bakırcıoglu Mustafa Emre, Ceyhan Erman, Aydos Kaan, Ramsay Jonathan, Minhas Suks, Al Hashimi Manaf, Ghayda Ramy Abou, Tadros Nicholas, Sindhwani Puneet, Ho Christopher C K, Rachman Rinaldo Indra, Rodriguez Pena Marcelo, Motawi Ahmad, Ponnusamy Arun Karthik, Dipankar Satish, Amir Azwar, Binsaleh Saleh, Serefoglu Ege Can, Banthia Ravi, Khalafalla Kareim, Basukarno Ari, Bac Nguyen Hoai, Singla Karun, Ambar Rafael F, Makarounis Konstantinos, Priyadarshi Shivam, Duarsa Gede Wirya Kusuma, Atmoko Widi, Jindal Sunil, Arianto Eko, Akhavizadegan Hamed, El Bardisi Haitham, Shoshany Ohad, Busetto Gian Maria, Moussa Mohamad, Jamali Mounir, Al-Marhoon Mohamed S, Ruzaev Mikhail, Farsi Hasan M A, Mutambirwa Shingai, Lee Dong Sup, Kulaksiz Deniz, Cheng Yu-Sheng, Bouzouita Abderrazak, Sarikaya Selcuk, Kandil Hussein, Tsampoukas Georgios, Farkouh Ala'a, Bowa Kasonde, Savira Missy, Mogharabian Nasser, Le Tan V, Harjanggi Maruto, Anh Dang Tuan, Long Tran Quang Tien, Soebadi Mohammad Ayodhia, Hakim Lukman, Tanic Marko, Ari Umut Cagin, Parikh Firuza R, Calik Gokhan, Kv Vinod, Dorji Gyem, Rezano Andri, Rajmil Osvaldo, Tien Dung Mai Ba, Yuan Yiming, Lizarraga-Salas Juan Francisco, Eze Balantine, Ngoo Kay Seong, Lee Joe, Arslan Umut, Agarwal Ashok, Global Andrology Forum
Аннотация
MATERIALS AND METHODS: The meta-analysis was performed according to PRISMA-P and MOOSE guidelines. A systematic search was performed in Scopus, PubMed, Cochrane, and Embase databases. Eligible studies were selected according to the PICOS model (Population: infertile male patients with clinical varicocele; Intervention: varicocele repair; Comparison: intra-person before-after varicocele repair; Outcome: conventional semen parameters; Study type: randomized controlled trials [RCTs], observational and case-control studies).
RESULTS: Out of 1,632 screened abstracts, 351 articles (23 RCTs, 292 observational, and 36 case-control studies) were included in the quantitative analysis. The before-and-after analysis showed significant improvements in all semen parameters after varicocele repair (except sperm vitality); semen volume: standardized mean difference (SMD) 0.203, 95% CI: 0.129-0.278; p<0.001; I²=83.62%, Egger's p=0.3329; sperm concentration: SMD 1.590, 95% CI: 1.474-1.706; p<0.001; I²=97.86%, Egger's p<0.0001; total sperm count: SMD 1.824, 95% CI: 1.526-2.121; p<0.001; I²=97.88%, Egger's p=0.0063; total motile sperm count: SMD 1.643, 95% CI: 1.318-1.968; p<0.001; I²=98.65%, Egger's p=0.0003; progressive sperm motility: SMD 1.845, 95% CI: 1.537%-2.153%; p<0.001; I²=98.97%, Egger's p<0.0001; total sperm motility: SMD 1.613, 95% CI 1.467%-1.759%; p<0.001; l2=97.98%, Egger's p<0.001; sperm morphology: SMD 1.066, 95% CI 0.992%-1.211%; p<0.001; I²=97.87%, Egger's p=0.1864.
CONCLUSIONS: The current meta-analysis is the largest to date using paired analysis on varicocele patients. In the current meta-analysis, almost all conventional semen parameters improved significantly following varicocele repair in infertile patients with clinical varicocele.