Basal Follicle-Stimulating Hormone or Inhibin B Combined with Age as Predictors of Pregnancy After Treatment by Donor Sperm Insemination.

OBJECTIVE

To evaluate the clinical significance of basal reproductive hormones and basal inhibin B (INHB) combined with age on predicting the outcomes of artificial insemination with donor sperm (AID).

STUDY

DESIGN

A retrospective analysis was performed in 1,772 patients who underwent AID at the Department of Assisted Re- production, Tongji Medical College, from 2009-2011. We compared the age and The levels of basal menstrual cycle day 3 reproductive hormones and INHB regarding the pregnancy rates after AID treatment.

RESULTS

There was a low clinical pregnancy rate in women with a basal follicle-stimulating hormone (FSH) ≥ 15 IU/L or a basal INHB < 25 ng/mL. An age-related decrease in the pregnancy rate was found also. Moreover, the pregnancy rate dropped remarkably when the FSH x age value was > 500, and it rose to 70.6% when the INHB ÷ age value was > 10.

CONCLUSION

Basal FSH and basal INHB are closely correlated with clinical pregnant rates in AID treatment. Furthermore, FSH x age and INHB ÷ age could be used as an optimal tool for predicting AID outcomes.