New perspectives for unexplained infertility.

For patients diagnosed with unexplained infertility, recent information has allowed the diagnosis to be viewed in a new light. With a better understanding of the efficacy and use of empiric therapies, unexplained infertility has gone from a diagnosis filled with uncertainty and despair to one that when treated appropriately has a positive outlook. Appropriate initial treatment for unexplained infertility can be managed in the office by generalists with the administration of oral ovulation induction medications combined with intrauterine insemination.