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Войти в исследования Fertility and sterility · 2004
Insemination with isolated and virologically tested spermatozoa is a safe way for human immunodeficiency type 1 virus-serodiscordant couples with an infected male partner to have a child.
Клиническое исследованиеСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Bujan Louis, Pasquier Christophe, Labeyrie Evelyne, Lanusse-Crousse Patrick, Morucci Mireille, Daudin Myriam
Аннотация
OBJECTIVE: To enable serodiscordant couples to reproduce while minimizing the risk of infecting the female partner and to demonstrate the feasibility of including these couples in an insemination program.
DESIGN: Prospective follow-up study.
SETTING: Ambulatory IUIs.
PATIENT(S): Fifty-six HIV-1-serodiscordant couples with a male infected partner.
INTERVENTION(S): Sperm cell separation by the gradient density method followed by the swim-up method, virological detection, and IUI after ovarian stimulation.
MAIN OUTCOME MEASURE(S): Pregnancy rate, HIV-1 test, and p24 antigenemia in women.
RESULT(S): Two hundred thirteen IUIs were performed, and 37 pregnancies occurred, resulting in 33 births and 2 ongoing pregnancies. Fifty percent of couples have a child. No women were infected.
CONCLUSION(S): Our study demonstrates the efficiency of an IUI program with prepared and virologically tested spermatozoa in serodiscordant couples with an HIV-1-infected male partner, allowing the couples to have children without transmission of the virus to the female partner.
DESIGN: Prospective follow-up study.
SETTING: Ambulatory IUIs.
PATIENT(S): Fifty-six HIV-1-serodiscordant couples with a male infected partner.
INTERVENTION(S): Sperm cell separation by the gradient density method followed by the swim-up method, virological detection, and IUI after ovarian stimulation.
MAIN OUTCOME MEASURE(S): Pregnancy rate, HIV-1 test, and p24 antigenemia in women.
RESULT(S): Two hundred thirteen IUIs were performed, and 37 pregnancies occurred, resulting in 33 births and 2 ongoing pregnancies. Fifty percent of couples have a child. No women were infected.
CONCLUSION(S): Our study demonstrates the efficiency of an IUI program with prepared and virologically tested spermatozoa in serodiscordant couples with an HIV-1-infected male partner, allowing the couples to have children without transmission of the virus to the female partner.