Inevitable risk of high-order multiple pregnancies following IUI, the need for strict criteria for its prevention: two case reports.

Intrauterine insemination with controlled super-ovulation (IUI/SO) is appropriate management of subfertility where the Fallopian tubes are healthy and patent and the sperm quality is satisfactory. The treatment is monitored by intermittent transvaginal ultrasound scans to assess follicular development. There is an unavoidable increased risk of multiple pregnancy including higher order pregnancy. These two case reports suggest the need for national standards regarding the abandonment of the treatment cycle to further reduce the risk of high order multiple implantations.