Fertility and sterility · 1998
Efficacy of treatment for unexplained infertility.
СтатьяНазвание и аннотация: Перевод в очереди
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Guzick D S, Sullivan M W, Adamson G D, Cedars M I, Falk R J, Peterson E P, Steinkampf M P
Аннотация
OBJECTIVE: To analyze the efficacy and cost-effectiveness of alternative treatments for unexplained infertility.
DESIGN: Retrospective analysis of 45 published reports.
SETTING: Clinical practices.
PATIENT(S): Couples who met criteria for unexplained infertility. Women with Stage I or Stage II endometriosis were included.
INTERVENTION(S): Observation; clomiphene citrate (CC); gonadotropins (hMG); IUI; and GIFT and IVF.
MAIN OUTCOME MEASURE(S): Clinical pregnancy rate.
RESULT(S): Combined pregnancy rates per initiated cycle, adjusted for study quality, were as follows: no treatment = 1.3%-4.1%; IUI = 3.8%; CC = 5.6%; CC + IUI = 8.3%; hMG = 7.7%; hMG + IUI = 17.1%; IVF = 20.7%; GIFT = 27.0%. The estimated cost per pregnancy was $10,000 for CC + IUI, $17,000 for hMG + IUI, and $50,000 for IVF.
CONCLUSION(S): Clomiphene citrate + IUI is a cost-effective treatment for unexplained infertility. If this treatment fails, hMG + IUI and assisted reproduction are efficacious therapeutic options.
DESIGN: Retrospective analysis of 45 published reports.
SETTING: Clinical practices.
PATIENT(S): Couples who met criteria for unexplained infertility. Women with Stage I or Stage II endometriosis were included.
INTERVENTION(S): Observation; clomiphene citrate (CC); gonadotropins (hMG); IUI; and GIFT and IVF.
MAIN OUTCOME MEASURE(S): Clinical pregnancy rate.
RESULT(S): Combined pregnancy rates per initiated cycle, adjusted for study quality, were as follows: no treatment = 1.3%-4.1%; IUI = 3.8%; CC = 5.6%; CC + IUI = 8.3%; hMG = 7.7%; hMG + IUI = 17.1%; IVF = 20.7%; GIFT = 27.0%. The estimated cost per pregnancy was $10,000 for CC + IUI, $17,000 for hMG + IUI, and $50,000 for IVF.
CONCLUSION(S): Clomiphene citrate + IUI is a cost-effective treatment for unexplained infertility. If this treatment fails, hMG + IUI and assisted reproduction are efficacious therapeutic options.