Fertility and sterility · 1998
The effectiveness of intrauterine insemination in couples with sterility due to male infertility with and without a woman's hormone factor.
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Rammer E, Friedrich F
Аннотация
OBJECTIVE: To examine the efficacy of IUI on fecundity and baby-take-home rates in cases of infertility attributable to a male factor with and without a woman's hormone factor.
DESIGN: Retrospective analysis.
SETTING: Department of Gynecology and Obstetrics at the General Public Hospital, Horn, Austria.
PATIENT(S): Seventy-eight long-standing involuntarily childless couples.
INTERVENTION(S): After a follicular phase GnRH analog (buserelin) protocol with hMG stimulation of the woman and a Percoll gradient preparation and capacitation of the man's semen, an IUI was performed.
MAIN OUTCOME MEASURE(S): Fecundity and baby-take-home rates.
RESULT(S): One hundred nine inseminations were followed by 53 pregnancies (48.6%; 95% confidence intervals (CI) 38.9%-58.4%) and 38 deliveries (34.9%; 95% CI 26.0%-44.6%). Forty-nine children were born and 47 are alive (43.1%).
CONCLUSION(S): Intrauterine insemination combined with buserelin gonadotropin stimulation, Percoll semen preparation, and sperm capacitation is a feasible solution to the problem of sterility attributable to a male factor with and without a woman's hormone factor.
DESIGN: Retrospective analysis.
SETTING: Department of Gynecology and Obstetrics at the General Public Hospital, Horn, Austria.
PATIENT(S): Seventy-eight long-standing involuntarily childless couples.
INTERVENTION(S): After a follicular phase GnRH analog (buserelin) protocol with hMG stimulation of the woman and a Percoll gradient preparation and capacitation of the man's semen, an IUI was performed.
MAIN OUTCOME MEASURE(S): Fecundity and baby-take-home rates.
RESULT(S): One hundred nine inseminations were followed by 53 pregnancies (48.6%; 95% confidence intervals (CI) 38.9%-58.4%) and 38 deliveries (34.9%; 95% CI 26.0%-44.6%). Forty-nine children were born and 47 are alive (43.1%).
CONCLUSION(S): Intrauterine insemination combined with buserelin gonadotropin stimulation, Percoll semen preparation, and sperm capacitation is a feasible solution to the problem of sterility attributable to a male factor with and without a woman's hormone factor.