Fertility and sterility · 1995
Determination of a maximum number of artificial inseminations by donor children per sperm donor.
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de Boer A, Oosterwijk J C, Rigters-Aris C A
Аннотация
OBJECTIVE: To determine a safe maximum number of artificial insemination (donor insemination [DI]) children per anonymous sperm donor.
DESIGN: Multiparameter calculation model of contribution of DI to inbreeding.
SETTING: Data of the collaborative DI centers and demographic population data of The Netherlands.
INTERVENTIONS: Calculations of the contribution of DI to inbreeding were made, taking into account all possible unintentional consanguineous matings and consanguineous inseminations with a coefficient of inbreeding (F) of > or = 1/16 for the offspring.
MAIN OUTCOME MEASURE: Coefficient of inbreeding (F).
RESULTS: The contribution of DI to inbreeding was estimated to be 46.6 x 10(-6) + k (1.66 x 10(-6)) (k = number of DI children per donor). When only half-sibling matings were considered, the kmax was 32. When all possible consanguineous matings and inseminations were taken into account, kmax decreased with 28% to 25 children.
CONCLUSION: Calculations of a maximum number of DI children per sperm donor, based on possible enhancement of inbreeding and given the Dutch population and DI setting, show that 25 children per DI donor is a safe threshold for clinical practice.
DESIGN: Multiparameter calculation model of contribution of DI to inbreeding.
SETTING: Data of the collaborative DI centers and demographic population data of The Netherlands.
INTERVENTIONS: Calculations of the contribution of DI to inbreeding were made, taking into account all possible unintentional consanguineous matings and consanguineous inseminations with a coefficient of inbreeding (F) of > or = 1/16 for the offspring.
MAIN OUTCOME MEASURE: Coefficient of inbreeding (F).
RESULTS: The contribution of DI to inbreeding was estimated to be 46.6 x 10(-6) + k (1.66 x 10(-6)) (k = number of DI children per donor). When only half-sibling matings were considered, the kmax was 32. When all possible consanguineous matings and inseminations were taken into account, kmax decreased with 28% to 25 children.
CONCLUSION: Calculations of a maximum number of DI children per sperm donor, based on possible enhancement of inbreeding and given the Dutch population and DI setting, show that 25 children per DI donor is a safe threshold for clinical practice.