Sperm-immobilizing antibodies in women undergoing artificial insemination with donor sperm.

Forty-nine female partners of infertile couples undergoing AID (1 to 44 times) were tested for the presence of sperm-immobilizing antibodies in their serum. One hundred fifty-one infertile women undergoing ART treatment other than AID were enrolled as a control group. One of the 49 AID patients and 3 of the 151 women of the control group were positive for sperm-immobilizing antibodies. The sperm-immobilizing antibodies incidence in AID patients did not differ significantly from that in the control group. This suggests that multiple exposures to semen from different donors do not increase the possibility of inducing sperm-immobilizing antibodies in AID patients.