Noise impairment in the guinea pig. II. Changes of single unit responses in the inferior colliculus.

Spontaneous and evoked activity of neurons in the inferior colliculus of guinea pigs was recorded before and after exposure to noise (continuous or intermittent white noise, 115 dB SPL for 30 min). A single unit was investigated in each animal, and its activity was monitored for several hours. Exposure to noise elevated the threshold of the tip of the tuning curve, resulting in a broadening of the tuning curve. Threshold elevation at the characteristic frequency was greater after exposure to intermittent noise (200 ms noise and 200 ms pause), reaching values of 22.8 +/- 3.7 dB (means +/- S.E.) than it was after exposure to continuous noise (threshold elevation of 13.1 +/- 1.7 dB). The average threshold shift was 17.1 +/- 2 dB. Neither the shape of the poststimulus histograms nor the slope of the spike-intensity curves changed with the noise exposure. The total number of spikes during the response was, however, reduced, and the reduction was in proportion to the threshold elevation. Monaural noise exposure had no effect on the neuronal activity evoked by stimulation of the opposite, nonexposed ear. The latencies of responses recorded after exposure to noise were also longer than the latencies at the same absolute intensity recorded before the exposure. Thus the latencies during the original pre-exposure and acquired postexposure thresholds were practically identical.