Fukushima journal of medical science · 2020
Autoantibodies associated with neuropsychiatric systemic lupus erythematosus: the quest for symptom-specific biomarkers.
СтатьяОбзорНазвание и аннотация: Перевод в очереди
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Sato Shuzo, Temmoku Jumpei, Fujita Yuya, Yashiro-Furuya Makiko, Matsuoka Naoki, Asano Tomoyuki, Kobayashi Hiroko, Watanabe Hiroshi, Migita Kiyoshi
Аннотация
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that affects multiple organs, including the central nervous system. Neuropsychiatric SLE (NPSLE) is a severe and potentially fatal condition. Several factors including autoantibodies have been implicated in the pathogenesis of NPSLE. However, definitive biomarkers of NPSLE are yet to be identified owing to the complexity of this disease. This is a major barrier to accurate and timely diagnosis of NPSLE. Studies have identified several autoantibodies associated with NPSLE;some of these autoantibodies are well investigated and regarded as symptom-specific. In this review, we discuss recent advances in our understanding of the manifestations and pathogenesis of NPSLE. In addition, we describe representative symptom-specific autoantibodies that are considered to be closely associated with the pathogenesis of NPSLE.