Automated Anatomical Landmark Localization in Anterior Segment OCT Images Using an Efficient Deep Learning Framework.

Anterior segment optical coherence tomography (AS-OCT) is essential for structural assessment of the anterior eye, yet automated landmark localization remains challenged by pervasive speckle noise, indistinct tissue interfaces, and labor-intensive manual annotation with notable inter-observer variability. This study presents NSE YOLO, an enhanced YOLOv11 framework for high-precision landmark localization in AS-OCT images after implantable collamer lens (ICL) implantation. It integrates a dual-branch NewConv module for multi-scale feature extraction, a dual-additive residual self-attention block (SABlock) to suppress background interference, and a Mamba-based EfficientViMBlock embedded in the C3k2 module to balance global contextual modeling and computational efficiency. Validated on 672 expert-annotated postoperative ICL images from 60 patients, NSE YOLO achieved an mAP@0.5 of 90.7% and mAP@0.5:0.95 of 85.1%, outperforming the YOLOv11 baseline by 5.2% and 6.6% with only 2.86 million parameters. Bland-Altman analysis showed negligible systematic bias and narrow limits of agreement for anterior chamber depth. For iridocorneal angle measurements, directional deviations and wider limits of agreement were observed, with performance approaching the level of inter-observer variability among human annotators. NSE YOLO enables automated quantification of anterior chamber depth and bilateral iridocorneal angles for post-ICL follow-up assessment, providing preliminary technical validation supporting further external and device-level evaluation.