Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus · 2026
Assessing visual and refractive outcomes of subretinal fluid detected by handheld swept-source optical coherence tomography in full-term newborns.
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Wang Debbie X, Hoyer Amanda R, Park Claire J, Legocki Alex T, Kelly John P, Monger Tatiana R, Lawson Sumner E, Elfwwal Mennatullah M, Liu Teng, Dang Joshua N, Ding Leona, Bunk Jason J, Wang Ruikang K, Tarczy-Hornoch Kristina, Cabrera Michelle T
Аннотация
BACKGROUND: Healthy, full-term newborns frequently present with foveal subretinal fluid (SRF), reported to spontaneously resolve within 1-4 months. The purpose of this study was to evaluate refractive and visual outcomes of SRF.
METHODS: In this prospective, single-institution study, healthy full-term infants were imaged using handheld swept-source optical coherence tomography between 12-72 hours after birth. OCT macular volumes were graded for SRF and foveal immaturity parameters. Participants returned at 9 months and 5 years for visual acuity and cycloplegic refraction assessments.
RESULTS: Of the 96 eyes (50 infants) imaged, 15 eyes (16%) of 10 infants had SRF. Eyes with SRF demonstrated greater central foveal thickness than those without SRF (202 ± 51 mm vs 149 ± 23 mm [P < 0.001]). No significant differences were found in inner or outer fovea/parafovea ratio, foveal or parafoveal choroidal thicknesses, or central neuroretinal thickness (P > 0.09). Mean spherical equivalent refraction was similar between groups at 9 months (1.71 ± 1.05 vs 1.53 ± 1.04 D [P = 0.88]; n = 29 eyes) and 5 years (0.63 ± 0.53 vs 1.79 ± 0.90 [P = 0.20]; n = 35 eyes). Mean logMAR visual acuities were similar between groups at 9 months (0.91 ± 0.36 vs 0.72 ± 0.19 [P = 0.62]) and 5 years (0.09 ± 0.12 vs 0.08 ± 0.10 [P = 0.75]).
CONCLUSIONS: In this small cohort, SRF in full-term newborns was not associated with foveal immaturity at birth or with negative refractive or visual outcomes up to 5 years. These results suggest that SRF is likely transient and benign.
METHODS: In this prospective, single-institution study, healthy full-term infants were imaged using handheld swept-source optical coherence tomography between 12-72 hours after birth. OCT macular volumes were graded for SRF and foveal immaturity parameters. Participants returned at 9 months and 5 years for visual acuity and cycloplegic refraction assessments.
RESULTS: Of the 96 eyes (50 infants) imaged, 15 eyes (16%) of 10 infants had SRF. Eyes with SRF demonstrated greater central foveal thickness than those without SRF (202 ± 51 mm vs 149 ± 23 mm [P < 0.001]). No significant differences were found in inner or outer fovea/parafovea ratio, foveal or parafoveal choroidal thicknesses, or central neuroretinal thickness (P > 0.09). Mean spherical equivalent refraction was similar between groups at 9 months (1.71 ± 1.05 vs 1.53 ± 1.04 D [P = 0.88]; n = 29 eyes) and 5 years (0.63 ± 0.53 vs 1.79 ± 0.90 [P = 0.20]; n = 35 eyes). Mean logMAR visual acuities were similar between groups at 9 months (0.91 ± 0.36 vs 0.72 ± 0.19 [P = 0.62]) and 5 years (0.09 ± 0.12 vs 0.08 ± 0.10 [P = 0.75]).
CONCLUSIONS: In this small cohort, SRF in full-term newborns was not associated with foveal immaturity at birth or with negative refractive or visual outcomes up to 5 years. These results suggest that SRF is likely transient and benign.