TSSK-Net: Weakly supervised biomarker localization and segmentation with image-level annotation in retinal OCT images.

The localization and segmentation of biomarkers in OCT images are critical steps in retina-related disease diagnosis. Although fully supervised deep learning models can segment pathological regions, their performance relies on labor-intensive pixel-level annotations. Compared with dense pixel-level annotation, image-level annotation can reduce the burden of manual annotation. Existing methods for image-level annotation are usually based on class activation maps (CAM). However, current methods still suffer from model collapse, training instability, and anatomical mismatch due to the considerable variation in retinal biomarkers' shape, texture, and size. This paper proposes a novel weakly supervised biomarkers localization and segmentation method, requiring only image-level annotations. The technique is a Teacher-Student network with joint Self-supervised contrastive learning and Knowledge distillation-based anomaly localization, namely TSSK-Net. Specifically, we treat retinal biomarker regions as abnormal regions distinct from normal regions. First, we propose a novel pre-training strategy based on supervised contrastive learning that encourages the model to learn the anatomical structure of normal OCT images. Second, we design a fine-tuning module and propose a novel hybrid network structure. The network includes supervised contrastive loss for feature learning and cross-entropy loss for classification learning. To further improve the performance, we propose an efficient strategy to combine these two losses to preserve the anatomical structure and enhance the encoding representation of features. Finally, we design a knowledge distillation-based anomaly segmentation method that is effectively combined with the previous model to alleviate the challenge of insufficient supervision. Experimental results on a local dataset and a public dataset demonstrated the effectiveness of our proposed method. Our proposed method can effectively reduce the annotation burden of ophthalmologists in OCT images.