Association of cytochrome P450 1B1 polymorphism with first-trimester miscarriage.

OBJECTIVE

To determine whether the cytochrome P450 1B1 (CYP1B1) Val432Leu polymorphism is associated with risk of miscarriage. We also analyzed the possible interaction between this polymorphism and caffeine intake.

DESIGN

The population-based case-control study included 507 women with miscarriage in the first trimester of pregnancy and 908 controls with a normal first-trimester pregnancy. The controls were frequency matched to cases. The material was analyzed taking maternal age, smoking habits, alcohol intake, caffeine intake, fetal karyotype, nausea, and vomiting into consideration.

SETTING

University hospital and primary care facility.

MAIN OUTCOME MEASURE(S): CYP1B1 Val432Leu genotype frequencies in cases and controls.

RESULT(S): Carriers of the CYP1B1 432 Val/Val genotype were at a higher risk of miscarriage in the first trimester of pregnancy (odds ratio = 1.46; 95% confidence interval, 1.02-2.08). We also found a significant interaction between genotype and caffeine intake.

CONCLUSION(S): CYP1B1 Val432Leu polymorphism is associated with first-trimester miscarriage, and it may also modify the risk among coffee drinkers.