Fertility and sterility · 2021
Mean differences in maternal body mass index and recurrent pregnancy loss: a systematic review and meta-analysis of observational studies.
СтатьяМетаанализПоддержка NIH: внешняя программаСистематический обзорНазвание и аннотация: Перевод в очереди
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Eapen Abey, Hayes Emily T, McQueen Dana B, Beestrum Molly, Eyck Patrick Ten, Boots Christina
Аннотация
OBJECTIVE: To investigate the association of maternal body mass index (BMI) and recurrent pregnancy loss (RPL).
DESIGN: Systematic review and meta-analysis.
SETTING: Not applicable.
PATIENT(S): A total of 3,833 women with RPL and 4,083 women as controls.
INTERVENTION(S): Studies were identified through a search of PubMed, Embase, Scopus, and Cochrane.
MAIN OUTCOME MEASURE(S): The primary outcome of interest was RPL using the mean differences in maternal BMI as the predictor variable. The results of the meta-analysis were reported as the mean difference with a 95% confidence interval.
RESULT(S): In total, 892 studies were reviewed. Pooled data from 25 studies suggested that the maternal BMI of women with a history of recurrent pregnancy loss was significantly higher than the BMI of controls, mean difference 0.7 kg/m2 [95% confidence interval 0.2-1.3].
CONCLUSION(S): These findings supported an association between maternal BMI and RPL. Large prospective studies are needed to evaluate the influence of maternal BMI on pregnancy outcomes in women with RPL.
DESIGN: Systematic review and meta-analysis.
SETTING: Not applicable.
PATIENT(S): A total of 3,833 women with RPL and 4,083 women as controls.
INTERVENTION(S): Studies were identified through a search of PubMed, Embase, Scopus, and Cochrane.
MAIN OUTCOME MEASURE(S): The primary outcome of interest was RPL using the mean differences in maternal BMI as the predictor variable. The results of the meta-analysis were reported as the mean difference with a 95% confidence interval.
RESULT(S): In total, 892 studies were reviewed. Pooled data from 25 studies suggested that the maternal BMI of women with a history of recurrent pregnancy loss was significantly higher than the BMI of controls, mean difference 0.7 kg/m2 [95% confidence interval 0.2-1.3].
CONCLUSION(S): These findings supported an association between maternal BMI and RPL. Large prospective studies are needed to evaluate the influence of maternal BMI on pregnancy outcomes in women with RPL.