Fertility and sterility · 2015
Relationship between sperm aneuploidy, sperm DNA integrity, chromatin packaging, traditional semen parameters, and recurrent pregnancy loss.
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Zidi-Jrah Ines, Hajlaoui Amani, Mougou-Zerelli Soumaya, Kammoun Molka, Meniaoui Imene, Sallem Amira, Brahem Sonia, Fekih Meriem, Bibi Mohammed, Saad Ali, Ibala-Romdhane Samira
Аннотация
OBJECTIVE: To study the possible relationship between sperm aneuploidy, sperm DNA integrity, chromatin packaging, traditional semen parameters, and recurrent pregnancy loss (RPL).
DESIGN: Descriptive study.
SETTING: University-affiliated tertiary teaching.
PATIENT(S): A total of 22 couples with history of RPL and 20 fertile men.
INTERVENTION(S): Semen samples from case and control men were examined for differences in semen parameters, DNA fragmentation, chromatin condensation, and sperm aneuploidy.
MAIN OUTCOME MEASURE(S): Sperm DNA and chromatin integrity and sperm aneuploidy.
RESULT(S): Sperm progressive motility (30.2% vs. 51.5%) was significantly lower and abnormal morphology (74.8% vs. 54.2%) was significantly higher in the RPL group versus the control group, respectively. The percentage of fragmented DNA was significantly increased in the RPL group (17.1% vs. 10.2%) as well as the rate of spermatozoa with nuclear chromatin decondensation (23.6% vs. 11.8%). There was a significantly higher sperm aneuploidy rate among the RPL group as well.
CONCLUSION(S): The increase in abnormal sperm parameters, sperm DNA fragmentation, nuclear chromatin decondensation, and sperm aneuploidy suggest possible causes of unexplained RPL.
DESIGN: Descriptive study.
SETTING: University-affiliated tertiary teaching.
PATIENT(S): A total of 22 couples with history of RPL and 20 fertile men.
INTERVENTION(S): Semen samples from case and control men were examined for differences in semen parameters, DNA fragmentation, chromatin condensation, and sperm aneuploidy.
MAIN OUTCOME MEASURE(S): Sperm DNA and chromatin integrity and sperm aneuploidy.
RESULT(S): Sperm progressive motility (30.2% vs. 51.5%) was significantly lower and abnormal morphology (74.8% vs. 54.2%) was significantly higher in the RPL group versus the control group, respectively. The percentage of fragmented DNA was significantly increased in the RPL group (17.1% vs. 10.2%) as well as the rate of spermatozoa with nuclear chromatin decondensation (23.6% vs. 11.8%). There was a significantly higher sperm aneuploidy rate among the RPL group as well.
CONCLUSION(S): The increase in abnormal sperm parameters, sperm DNA fragmentation, nuclear chromatin decondensation, and sperm aneuploidy suggest possible causes of unexplained RPL.