Peripheral Nervous System Disease in Systemic Lupus Erythematosus: Results From an International Inception Cohort Study.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Hanly John G, Li Qiuju, Su Li, Urowitz Murray B, Gordon Caroline, Bae Sang-Cheol, Romero-Diaz Juanita, Sanchez-Guerrero Jorge, Bernatsky Sasha, Clarke Ann E, Wallace Daniel J, Isenberg David A, Rahman Anisur, Merrill Joan T, Fortin Paul R, Gladman Dafna D, Bruce Ian N, Petri Michelle, Ginzler Ellen M, Dooley M A, Steinsson Kristjan, Ramsey-Goldman Rosalind, Zoma Asad A, Manzi Susan, Nived Ola, Jonsen Andreas, Khamashta Munther A, Alarcón Graciela S, Svenungsson Elisabet, van Vollenhoven Ronald F, Aranow Cynthia, Mackay Meggan, Ruiz-Irastorza Guillermo, Ramos-Casals Manuel, Lim S Sam, Inanc Murat, Kalunian Kenneth C, Jacobsen Soren, Peschken Christine A, Kamen Diane L, Askanase Anca, Theriault Chris, Farewell Vernon
Аннотация
METHODS: Patients were evaluated annually for 19 neuropsychiatric (NP) events including 7 types of PNS disease. SLE disease activity, organ damage, autoantibodies, and patient and physician assessment of outcome were measured. Time to event and linear regressions were used as appropriate.
RESULTS: Of 1,827 SLE patients, 88.8% were female, and 48.8% were white. The mean ± SD age was 35.1 ± 13.3 years, disease duration at enrollment was 5.6 ± 4.2 months, and follow-up was 7.6 ± 4.6 years. There were 161 PNS events in 139 (7.6%) of 1,827 patients. The predominant events were peripheral neuropathy (66 of 161 [41.0%]), mononeuropathy (44 of 161 [27.3%]), and cranial neuropathy (39 of 161 [24.2%]), and the majority were attributed to SLE. Multivariate Cox regressions suggested longer time to resolution in patients with a history of neuropathy, older age at SLE diagnosis, higher SLE Disease Activity Index 2000 scores, and for peripheral neuropathy versus other neuropathies. Neuropathy was associated with significantly lower Short Form 36 (SF-36) physical and mental component summary scores versus no NP events. According to physician assessment, the majority of neuropathies resolved or improved over time, which was associated with improvements in SF-36 summary scores for peripheral neuropathy and mononeuropathy.
CONCLUSION: PNS disease is an important component of total NPSLE and has a significant negative impact on health-related quality of life. The outcome is favorable for most patients, but our findings indicate that several factors are associated with longer time to resolution.