The Expression and Clinical Value of miR-483-5p in Cervical Cancer and Its Regulation of Cervical Cancer via TIMP2.

BackgroundCervical cancer (CC) is a major public health issue threatening women's health, and its early diagnosis and prognosis evaluation are very important. miR-483-5p has been identified as an oncogene in multiple cancers, but its molecular mechanism in CC is still unclear.ObjectiveThis study aims to explore the biological functions and regulatory mechanisms of miR-483-5p in CC.MethodsmiR-483-5p expression levels in CC were detected by qRT-PCR. The prognostic value of miR-483-5p was established via Kaplan-Meier survival analysis and Cox regression analysis. CCK-8 and Transwell assays served to analyze its regulatory effects on CC cell proliferation, migration, and invasion. Dual luciferase reporter assay validated the targeted binding relationship between miR-483-5p and TIMP2. Co-inhibition assays investigated the molecular mechanism of miR-483-5p in CC.ResultsmiR-483-5p is significantly increased in CC (p ConclusionsmiR-483-5p is significantly overexpressed in CC and functions as an oncogene by directly targeting and suppressing TIMP2 expression, thereby promoting cancer cell malignant progression.