Differences in overall survival for invasive epithelial ovarian cancer by race and ethnicity: results from the Ovarian Cancer Association Consortium.
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Meagher Nicola S, White Kami K, Wilkens Lynne R, Anton-Culver Hoda, Bandera Elisa V, Carney Michael E, Cramer Daniel W, Cushing-Haugen Kara L, DeFazio Anna, Doherty Jennifer A, Gentry-Maharaj Aleksandra, Goode Ellen L, Goodman Marc T, Harris Holly R, Karlan Beth Y, Kaufmann Scott H, Kelemen Linda E, Köbel Martin, Koziak Jennifer M, Le Marchand Loic, Lester Jenny, McGuire Valerie, Menon Usha, Modugno Francesmary, Moysich Kirsten B, Pearce Celeste Leigh, Pharoah Paul D P, Pike Malcolm C, Qin Bo, Risch Harvey A, Rothstein Joseph H, Sarink Danja, Sieh Weiva, Steed Helen, Terry Kathryn L, Thompson Pamela J, Titus Linda J, Van Gorp Toon, Whittemore Alice S, Winham Stacey J, Jordan Susan J, Wu Anna H, Webb Penelope M, AOCS Group, Peres Lauren C, Merritt Melissa A
Аннотация
METHODS: We analysed data from 18 Ovarian Cancer Association Consortium studies, including women with EOC from Asian (n = 697), non-Hispanic Black (n = 267), Hispanic (n = 492), Native Hawaiian/Pacific Islander (n = 98) and non-Hispanic White (n = 12,998) racial and ethnic groups. We ran Cox proportional hazards models estimating overall survival by race and ethnicity, adjusting for age, stage, year of diagnosis, and histotype, with fully adjusted models accounting for body mass index, smoking, and postmenopausal hormone use. We also examined associations between hormone-related factors and family history and overall survival by race and ethnicity, testing for heterogeneity.
RESULTS: Compared to non-Hispanic White women with EOC, Native Hawaiian/Pacific Islander and non-Hispanic Black women had poorer overall survival (Hazard Ratios, HR = 1.58, 95% CI = 1.16-2.16, and HR = 1.31, 95% CI = 1.12-1.54, respectively). The association was more pronounced for Native Hawaiian/Pacific Islander women with high-grade serous carcinoma (HR = 2.00, 95% CI = 1.37-2.92). There was no significant heterogeneity in the associations between epidemiological factors and survival by racial and ethnic groups (p ≥ 0.31).
DISCUSSION: Native Hawaiian/Pacific Islander and non-Hispanic Black women with EOC had poorer survival, highlighting the need to address disparities in outcome.