Медицинская библиотека · bioRxiv : the preprint server for biology · 2025
Robust inference and widespread genetic correlates from a large-scale genetic association study of human personality.
Schwaba Ted, Clapp Sullivan Margaret L, Akingbuwa Wonuola A, Ilves Kerli, Tanksley Peter T, Williams Camille M, Dragostinov Yavor, Liao Wangjingyi, Ackerman Lindsay S, Fealy Josephine C M, Hemani Gibran, de la Fuente Javier, Gupta Priya, Stein Murray B, Gelernter Joel, Levey Daniel F, Võsa Urmo, Ausmees Liisi, Realo Anu, Estonian Biobank Research Team, Vaht Mariliis, Allik Jüri, Esko Tõnu, Mõttus René, Vainik Uku, Jonsdottir Gudrun A, Thorleifsson Gudmar, Gunnarsson Árni Freyr, Bjornsdottir Gyda, Thorgeirsson Thorgeir E, Stefansson Hreinn, Stefansson Kari, Cheesman Rosa, Qin Qi, Corfield Elizabeth C, Ask Helga, Torvik Fartein Ask, Ystrom Eivind, Tesli Martin, Boomsma Dorret I, de Geus Eco J C, Hottenga Jouke-Jan, Melo Dener Cardoso, Snieder Harold, Hartman Catharina A, Xia Charley, Campbell Archie, Luciano Michelle, Deary Ian J, Hill W David, Jang Seon-Kyeong, Vrieze Scott I, Abecasis Gonçalo, Lupton Michelle K, Mitchell Brittany L, Viher Petra V, Colodro-Conde Lucía, Martin Nicholas G, Medland Sarah E, Derks Eske M, Wormington Briar, Kaprio Jaakko, Silventoinen Karri, Palviainen Teemu, Gidziela Agnieszka, Rimfeld Kaili, Plomin Robert, Malanchini Margherita, Dick Danielle M, Aliev Fazil, COGA Collaborators, The Spit for Science Working Group, Wesseldijk Laura W, Ullén Fredrik, Mosing Miriam A, Kranzler Henry R, Nunez Yaira, Beck Sarah, Polimanti Renato, Edwards Tobias, Giannelis Alexandros, Willoughby Emily A, Lee James J, McGue Matt, Terracciano Antonio, Marongiu Michele, Fiorillo Edoardo, Cucca Francesco, Sutin Angelina R, van der Most Peter J, Oldehinkel Albertine J, Kretschmer Tina, Shabalin Andrey A, Docherty Anna R, Krueger Robert F, Freilich Colin D, Mishra Binisha H, Lehtimäki Terho, Raitakari Olli T, Kähönen Mika, Saarinen Aino, Dobewall Henrik, Keltikangas-Järvinen Liisa, Berger Klaus, Herrera-Rivero Marisol, Streit Fabian, Awasthi Swapnil, Witt Stephanie H, Tuhkanen Johanna, Räikkönen Katri, Eriksson Johan G, Lahti Jari, Davies Gail, Redmond Paul, Taylor Adele, Corley Janie, Russ Tom C, Ciullo Marina, Nutile Teresa, Ding Jun, Qian Yong, Tanaka Toshiko, Ferrucci Luigi, Zillich Lea, Sirignano Lea, Harden K Paige, Genç Erhan, Gajewski Patrick D, Getzmann Stephan, Fraenz Christoph, Schneider Peñate Javier E, Lis Stefanie, Hall Alisha S M, Schmahl Christian, Herpertz Sabine C, Abdellaoui Abdel, Nivard Michel G, Tucker-Drob Elliot M
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Аннотация
Personality traits describe stable differences in how individuals think, feel, and behave and how they interact with and experience their social and physical environments. We assemble data from 46 cohorts including 611K-1.14M participants with European-like and African-like genomes for genome-wide association studies (GWAS) of the Big Five personality traits (extraversion, agreeableness, conscientiousness, neuroticism, and openness to experience), and data from 51K participants for within-family GWAS. We identify 1,257 lead genetic variants associated with personality, including 823 novel variants. Common genetic variants explain 4.8%-9.3% of the variance in each trait, and 10.5%-16.2% accounting for measurement unreliability. Genetic effects on personality are highly consistent across geography, reporter (self vs. close other), age group, and measurement instrument, and we find minimal spousal assortment for personality in recent history. In stark contrast to many other social and behavioral traits, within-family GWAS and polygenic index analyses indicate little to no shared environmental confounding in genetic associations with personality. Polygenic prediction, genetic correlation, and Mendelian randomization analyses indicate that personality genetics have widespread, potentially causal associations with a wide range of consequential behaviors and life outcomes. The genetic architecture of personality is robust and fundamental to being a human.
Для цитирования: Schwaba Ted, Clapp Sullivan Margaret L, Akingbuwa Wonuola A, Ilves Kerli, Tanksley Peter T, Williams Camille M, Dragostinov Yavor, Liao Wangjingyi, Ackerman Lindsay S, Fealy Josephine C M, Hemani Gibran, de la Fuente Javier, Gupta Priya, Stein Murray B, Gelernter Joel, Levey Daniel F, Võsa Urmo, Ausmees Liisi, Realo Anu, Estonian Biobank Research Team, Vaht Mariliis, Allik Jüri, Esko Tõnu, Mõttus René, Vainik Uku, Jonsdottir Gudrun A, Thorleifsson Gudmar, Gunnarsson Árni Freyr, Bjornsdottir Gyda, Thorgeirsson Thorgeir E, Stefansson Hreinn, Stefansson Kari, Cheesman Rosa, Qin Qi, Corfield Elizabeth C, Ask Helga, Torvik Fartein Ask, Ystrom Eivind, Tesli Martin, Boomsma Dorret I, de Geus Eco J C, Hottenga Jouke-Jan, Melo Dener Cardoso, Snieder Harold, Hartman Catharina A, Xia Charley, Campbell Archie, Luciano Michelle, Deary Ian J, Hill W David, Jang Seon-Kyeong, Vrieze Scott I, Abecasis Gonçalo, Lupton Michelle K, Mitchell Brittany L, Viher Petra V, Colodro-Conde Lucía, Martin Nicholas G, Medland Sarah E, Derks Eske M, Wormington Briar, Kaprio Jaakko, Silventoinen Karri, Palviainen Teemu, Gidziela Agnieszka, Rimfeld Kaili, Plomin Robert, Malanchini Margherita, Dick Danielle M, Aliev Fazil, COGA Collaborators, The Spit for Science Working Group, Wesseldijk Laura W, Ullén Fredrik, Mosing Miriam A, Kranzler Henry R, Nunez Yaira, Beck Sarah, Polimanti Renato, Edwards Tobias, Giannelis Alexandros, Willoughby Emily A, Lee James J, McGue Matt, Terracciano Antonio, Marongiu Michele, Fiorillo Edoardo, Cucca Francesco, Sutin Angelina R, van der Most Peter J, Oldehinkel Albertine J, Kretschmer Tina, Shabalin Andrey A, Docherty Anna R, Krueger Robert F, Freilich Colin D, Mishra Binisha H, Lehtimäki Terho, Raitakari Olli T, Kähönen Mika, Saarinen Aino, Dobewall Henrik, Keltikangas-Järvinen Liisa, Berger Klaus, Herrera-Rivero Marisol, Streit Fabian, Awasthi Swapnil, Witt Stephanie H, Tuhkanen Johanna, Räikkönen Katri, Eriksson Johan G, Lahti Jari, Davies Gail, Redmond Paul, Taylor Adele, Corley Janie, Russ Tom C, Ciullo Marina, Nutile Teresa, Ding Jun, Qian Yong, Tanaka Toshiko, Ferrucci Luigi, Zillich Lea, Sirignano Lea, Harden K Paige, Genç Erhan, Gajewski Patrick D, Getzmann Stephan, Fraenz Christoph, Schneider Peñate Javier E, Lis Stefanie, Hall Alisha S M, Schmahl Christian, Herpertz Sabine C, Abdellaoui Abdel, Nivard Michel G, Tucker-Drob Elliot M. Robust inference and widespread genetic correlates from a large-scale genetic association study of human personality.. bioRxiv : the preprint server for biology. 2025. DOI: 10.1101/2025.05.16.648988.
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