Advanced materials (Deerfield Beach, Fla.) · 2023
Unmanned Aerial Vehicle Mediated Drug Delivery for First Aid.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Sheng Tao, Jin Rui, Yang Changwei, Qiu Ke, Wang Mingyang, Shi Jiaqi, Zhang Jingyu, Gao Yuman, Wu Qing, Zhou Xin, Wang Hao, Zhang Juan, Fang Qin, Pan Neng, Xue Yanan, Wang Yue, Xiong Rong, Gao Fei, Zhang Yuqi, Lu Haojian, Yu Jicheng, Gu Zhen
Аннотация
Timely administration of key medications toward patients with sudden diseases is critical to saving lives. However, slow transport of first-aid therapeutics and the potential absence of trained people for drug usage can lead to severe injuries or even death. Herein, an unmanned aerial vehicle (UAV)-mediated first-aid system for targeted delivery (uFAST) is developed. It allows unattended administration of emergency therapeutics-loaded transdermal microneedle (MN) patches toward patients to relieve symptoms by a contact-triggered microneedle applicator (CTMA). The implementability and safety of the uFAST for first aid is demonstrated in a severe hypoglycemic pig model by automatically delivering a glucagon patch with immediate and bioresponsive dual release modes. This platform technique may facilitate the development of UAV-mediated first-aid treatments for other sudden diseases.