Nature microbiology · 2026
LRP8 is a functional receptor for yellow fever virus.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Mei Miao, Yang Yang, Zhang Zihan, Yin Yue, Tan Jiali, Jiang Chao, Gao Yu, Wang Zhaoyang, Wang Donghong, Li Yajing, Cong Yingyi, Zhang Zhiyuan, Peng Yousong, Tan Wenjie, Li Jiandong, Li Li, Wang Hanxuan, Lang Ren, He Qiang, Deng Zihou, Huang Xiaojie, Luo Bin, Shan Chao, Zhang Yonghong, Mei Lin, Cheng Gong, Tan Xu
Аннотация
Yellow fever virus (YFV) is an arbovirus causing substantial human morbidity and mortality. The live-attenuated 17D strain serves as vaccine and is one of the most successful vaccines so far. Receptor usage between attenuated and pathogenic YFV strains remains unclear. Here we performed a barcoded, genome-wide human open-reading frame library screen and identified LRP8 (also named APOER2) as a receptor for YFV. We show that LRP8 expression increases YFV infection (17D and two clinical strains, BJ01 and Asibi) in cell lines by promoting entry. Adeno-associated virus-mediated expression of human LRP8 in mouse liver aggravates infection and pathology of the clinical strain BJ01. LRP8 knockdown decreases YFV infection in brain cells, primary human hepatocytes and mosquitoes. LRP8 directly interacts with YFV 17D particles via the viral envelope protein. A soluble LRP8 decoy protein can block YFV 17D and BJ01 infection. Our findings provide insights for understanding YFV entry, tropism and pathogenesis.