Comparative Analysis of Geriatric and Adult Drug Clinical Trials on ClinicalTrials.gov.

Clinical trials generate gold standard medical evidence, but are often criticized for the lack of population representativeness. We performed a comparative meta-analysis of drug trials that focus on older adults (>= 65 years old) and adults (18-64 years old). The major finding is that a higher percentage of geriatric drug trials were terminated or withdrawn than that of adult drug trials.