Acta obstetricia et gynecologica Scandinavica · 2010
Effect of high parity on the occurrence of prediabetes: a cohort study.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Al-Farsi Yahya M, Brooks Daniel R, Werler Martha M, Cabral Howard J, Al-Shafei Mohammed A, Wallenburg Henk C
Аннотация
OBJECTIVE: To assess the effect of parity on the occurrence of prediabetes defined as an abnormal fasting plasma glucose (5.6-6.9 mmol/l), an abnormal 2-hour oral glucose tolerance test (7.7-11.1 mmol/l), or both, before 12 weeks gestation or at least 6 weeks after delivery.
DESIGN: Retrospective cohort study.
SETTING: Nested on a community trial Delaying the Development of Diabetes Mellitus type 2 (AMAL study) in Oman.
POPULATION: 532 women with a total of 3,196 pregnancies.
METHODS: We conducted sets of Cox proportional hazard regression analyses: crude, age-adjusted and full models which adjusted for maternal age, education, family income and year of delivery.
MAIN OUTCOME MEASURES: Hazard ratio (HR) of the effect of parity on prediabetes.
RESULTS: We enumerated 258 cases of prediabetes over 8,529 person-years of follow up. In the crude model, high parity (> or =5) pregnancies carried a higher risk of prediabetes than low parity (<5) pregnancies (HR = 3.72; 95% CI = 2.80, 4.91), and the prediabetes incidence rate increased in a dose-response fashion over multiple categories of parity. In age-only models, the association attenuated with control of the confounding effect of maternal age (HR = 1.05; 95% CI = 0.76, 1.45). Adjusting for other confounders in the full models yielded similar results to those adjusted for maternal age only.
CONCLUSIONS: The apparent effect of parity on the occurrence of prediabetes is attributable to the confounding effect of maternal age rather than to high parity.
DESIGN: Retrospective cohort study.
SETTING: Nested on a community trial Delaying the Development of Diabetes Mellitus type 2 (AMAL study) in Oman.
POPULATION: 532 women with a total of 3,196 pregnancies.
METHODS: We conducted sets of Cox proportional hazard regression analyses: crude, age-adjusted and full models which adjusted for maternal age, education, family income and year of delivery.
MAIN OUTCOME MEASURES: Hazard ratio (HR) of the effect of parity on prediabetes.
RESULTS: We enumerated 258 cases of prediabetes over 8,529 person-years of follow up. In the crude model, high parity (> or =5) pregnancies carried a higher risk of prediabetes than low parity (<5) pregnancies (HR = 3.72; 95% CI = 2.80, 4.91), and the prediabetes incidence rate increased in a dose-response fashion over multiple categories of parity. In age-only models, the association attenuated with control of the confounding effect of maternal age (HR = 1.05; 95% CI = 0.76, 1.45). Adjusting for other confounders in the full models yielded similar results to those adjusted for maternal age only.
CONCLUSIONS: The apparent effect of parity on the occurrence of prediabetes is attributable to the confounding effect of maternal age rather than to high parity.