Revista medica de Chile · 2006
[The frequency of twin pregnancies increased in a Chilean hospital associated with periconceptional flour folic acid supplementation].
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Nazer H Julio, Aguila R Alfredo, Cifuentes O Lucía
Аннотация
BACKGROUND: A significant increase in the frequency of twins has been described in the literature as a secondary effect of perinatal supplementation with folic acid.
AIM: To verify if the frequency of twins increased in a Chilean hospital, after the start of flour folic acid supplementation.
MATERIAL AND METHODS: The frequency of twins was compared in the University of Chile Clinical Hospital, before and after the start of flour fortification with folic acid.
RESULTS: There was a 34% increase in the frequency of twins during the post fortification period (2001-2004) as compared with the previous period (1998-2000). A decrease in the frequency of male twins, when compared with single newborns, was also observed in the post fortification period. There was a higher frequency of stillborns among twins, when compared with single newborns.
CONCLUSIONS: The frequency of twin pregnancies increased after flour folic acid supplementation in sample of Chilean population.
AIM: To verify if the frequency of twins increased in a Chilean hospital, after the start of flour folic acid supplementation.
MATERIAL AND METHODS: The frequency of twins was compared in the University of Chile Clinical Hospital, before and after the start of flour fortification with folic acid.
RESULTS: There was a 34% increase in the frequency of twins during the post fortification period (2001-2004) as compared with the previous period (1998-2000). A decrease in the frequency of male twins, when compared with single newborns, was also observed in the post fortification period. There was a higher frequency of stillborns among twins, when compared with single newborns.
CONCLUSIONS: The frequency of twin pregnancies increased after flour folic acid supplementation in sample of Chilean population.