Vaccines · 2025
Safety and Immunogenicity of the Attenuated Yellow Fever Vaccine in Several Neotropical Primate Species.
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Paula Nayara Ferreira de, Vieira André Duarte, Santos Daniel Oliveira Dos, Souza Lucas Dos Reis de, Coelho Carlyle Mendes, Tinoco Herlandes Penha, Lima Paula Cristina Senra, Motta Rafael Otávio Cançado, Pereira Valéria do Socorro, Carvalho Marcelo Pires Nogueira de, Fernandes Camilla Bayma, Azevedo Adriana de Souza, Arruda Matheus Soares, Costa Thais Alkifeles, Drumond Betania Paiva, Leme Fabiola de Oliveira Paes, Freire Marcos da Silva, Paixão Tatiane Alves da, Oliveira Ayisa Rodrigues, Santos Renato Lima
Аннотация
BACKGROUND/OBJECTIVE: Yellow fever (YF) is an acute infectious disease caused by the yellow fever virus which is transmitted by mosquitoes. Neotropical primates are susceptible to infection, which is often presented as epizootic outbreaks. The aim was to evaluate and characterize the immune response against YF in different species of neotropical primates from the Belo Horizonte Zoo.
METHODS: Vaccine 17DD was administered to 24 neotropical primates, with a single subcutaneous dose. Clinical exams, RNAemia, and detection of IgG and neutralizing antibodies against YFV were performed. In addition, an ethogram was performed to assess clinical changes and animal welfare.
RESULTS: At 4 days post-vaccination, RNAemia was detected in nine animals. There was seroconversion and persistence of immune response in Alouatta guariba clamitans, Sapajus xanthosternos, Saguinus imperator and Aotus infulatus. However, the vaccine was not immunogenic for Lagothrix cana. In Pithecia irrorata seroconversion did not persist long term, while the Ateles sp. had a transient immune response. No significant clinical manifestations were observed in any of the vaccinated animals.
CONCLUSIONS: This study demonstrated a safe, immunogenic and persistent immune response induced by the attenuated 17DD vaccine strain in A. guariba clamitans, S. xanthosternos, S. imperator, and A. infulatus.
METHODS: Vaccine 17DD was administered to 24 neotropical primates, with a single subcutaneous dose. Clinical exams, RNAemia, and detection of IgG and neutralizing antibodies against YFV were performed. In addition, an ethogram was performed to assess clinical changes and animal welfare.
RESULTS: At 4 days post-vaccination, RNAemia was detected in nine animals. There was seroconversion and persistence of immune response in Alouatta guariba clamitans, Sapajus xanthosternos, Saguinus imperator and Aotus infulatus. However, the vaccine was not immunogenic for Lagothrix cana. In Pithecia irrorata seroconversion did not persist long term, while the Ateles sp. had a transient immune response. No significant clinical manifestations were observed in any of the vaccinated animals.
CONCLUSIONS: This study demonstrated a safe, immunogenic and persistent immune response induced by the attenuated 17DD vaccine strain in A. guariba clamitans, S. xanthosternos, S. imperator, and A. infulatus.