[The analysis of incidence of selected types of birth defects in the Czech Republic according to a multiplicity of pregnancy].

OBJECTIVE

To analyze an occurrence of selected types of birth defects in single and multiple pregnancies in the Czech Republic in 1994-2006 period.

DESIGN

A retrospective epidemiological analysis of birth defects according to a multiplicity of pregnancy.

SETTING

Department of Medical Genetics, Thomayer's University Hospital, Prague. Chair of Medical Genetics, Postgraduate Medical Institute, Prague.

METHODS

Data were collected from National Birth Defects Register (Institute of Health Information and Statistics). Incidences of selected types of birth defects according to pregnancy multiplicity were analyzed.

RESULTS

In 1994-2006, totally 1 132 567 children were born in the Czech Republic, out of which more than 42 000 with a birth defect. In all particular defects, incidences were increased in children born from multiple pregnancies compared to singletons.

CONCLUSION

Highest differences in birth defects incidences in children born from single versus multiple pregnancies were found in neural tube defects group and in congenital hydrocephalus.