European journal of obstetrics, gynecology, and reproductive biology · 2026
Clinical and biological characteristics of dengue in pregnant women in Reunion Island: A nested case-control analysis in the EPIDENGUE cohort study.
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Etoa Ndoko Anne Cécilia, Tran Phuong Lien, Lafont Marine, Diarra Yves Marie, Boukerrou Malik, Bertolotti Antoine, Gérardin Patrick
Аннотация
INTRODUCTION: Dengue is globally the most widespread arboviral disease, especially in tropical and subtropical regions. The primary aim of this study was to compare clinical and biological characteristics of dengue in pregnant and non-pregnant women on Reunion Island.
METHODS: In the EPIDENGUE retrospective cohort conducted in University Hospital Center (CHU) of Saint Pierre, Réunion Island, between January 1, 2019, and June 30, 2019, we matched pregnant women ("PWG", cases) and non-pregnant women ("NPWG", controls) infected with dengue on age and identified the characteristics associated with dengue in pregnant women using a conditional logistic regression model.
RESULTS: Among 274 female patients (median age 28.3 years) that were matched, patients in the PWG were more likely to develop pruritus (OR 5.18 [95 %CI 1.34-20.08] p = 0.017), less likely to experience anorexia (OR 0.19 [95 %CI 0.06-0.59] (p = 0.004), fever (OR 0.15 [95 %CI 0.04-0.65], p = 0.012), or to have a hematocrit of 38 % or above (OR 0.05 [95 %CI 0.01-0.22] p < 0.001) once controlled age, as compared to NPWG. We observed a non-significant trend towards a higher hematocrit level in women presenting warning signs (34.7 % vs 34.2 %, p = 0.084).
CONCLUSION: This nested case-control analysis highlights several clinical and-biological differences between pregnant and non-pregnant women with dengue, which are important to consider for avoiding the overdiagnosis of intrahepatic cholestasis of pregnancy and tailoring the monitoring of dengue in pregnant women. That implies screening for anorexia, fever and increase in hematocrit (prior to the decrease in platelet counts) as potential harbingers of progression to dengue with warning signs.
METHODS: In the EPIDENGUE retrospective cohort conducted in University Hospital Center (CHU) of Saint Pierre, Réunion Island, between January 1, 2019, and June 30, 2019, we matched pregnant women ("PWG", cases) and non-pregnant women ("NPWG", controls) infected with dengue on age and identified the characteristics associated with dengue in pregnant women using a conditional logistic regression model.
RESULTS: Among 274 female patients (median age 28.3 years) that were matched, patients in the PWG were more likely to develop pruritus (OR 5.18 [95 %CI 1.34-20.08] p = 0.017), less likely to experience anorexia (OR 0.19 [95 %CI 0.06-0.59] (p = 0.004), fever (OR 0.15 [95 %CI 0.04-0.65], p = 0.012), or to have a hematocrit of 38 % or above (OR 0.05 [95 %CI 0.01-0.22] p < 0.001) once controlled age, as compared to NPWG. We observed a non-significant trend towards a higher hematocrit level in women presenting warning signs (34.7 % vs 34.2 %, p = 0.084).
CONCLUSION: This nested case-control analysis highlights several clinical and-biological differences between pregnant and non-pregnant women with dengue, which are important to consider for avoiding the overdiagnosis of intrahepatic cholestasis of pregnancy and tailoring the monitoring of dengue in pregnant women. That implies screening for anorexia, fever and increase in hematocrit (prior to the decrease in platelet counts) as potential harbingers of progression to dengue with warning signs.