European archives of psychiatry and clinical neuroscience · 2026
Birth seasonality and height in patients with schizophrenia: a multi-institutional cohort study.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод в очереди
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Hsu Chih-Wei, Wang Liang-Jen, Vazquez-Bourgon Javier, Fernandez-Egea Emilio, Ortuño Felipe, Brugos-Larumbe Antonio, Guillen-Grima Francisco, Hjorthøj Carsten, Bitanihirwe Byron, Rodriguez-Torrella Claudia, Guasch-Capella Nora, Garcia-Rizo Clemente, Garriga Marina
Аннотация
PURPOSE: Schizophrenia is a psychiatric condition characterized by different physical liabilities, including reduced height, increased medical comorbidity, and reduced life expectancy. Schizophrenia stems from gene-environment interactions, with winter birth being a widely replicated environmental risk factor associated with more severe outcomes. We aim to investigate the association between winter birth and height in individuals with schizophrenia.
METHODS: 15181 individuals diagnosed with schizophrenia and with recorded height and date of birth, comprising 7414 males and 7767 females from the Chang Gung Research Database from Taiwan, were included.
RESULTS: Winter-born patients were the shortest (161.9 ± 8.8 cm), but the seasonal effect was non-significant after adjusting for sex and age (F = 2.4, p = 0.063). February-born patients were the shortest (161.5 ± 8.8 cm), and the monthly effect was significant after adjusting for sex and age (total sample, p = 0.038; females, p = 0.021). No significant effect was detected in male patients regarding the season/month of birth. After correction for multiple comparisons, the seasonal contrasts were no longer significant, whereas a subset of month-of-birth contrasts persisted.
CONCLUSIONS: Our results revealed a descriptive gradient where winter birth (specifically February) was associated with the shortest adult stature, a trend more pronounced among female patients. These findings suggest that winter birth is not only a risk factor for schizophrenia but may also impact anthropometry. Further research needs to examine potential etiologic causes for this association.
METHODS: 15181 individuals diagnosed with schizophrenia and with recorded height and date of birth, comprising 7414 males and 7767 females from the Chang Gung Research Database from Taiwan, were included.
RESULTS: Winter-born patients were the shortest (161.9 ± 8.8 cm), but the seasonal effect was non-significant after adjusting for sex and age (F = 2.4, p = 0.063). February-born patients were the shortest (161.5 ± 8.8 cm), and the monthly effect was significant after adjusting for sex and age (total sample, p = 0.038; females, p = 0.021). No significant effect was detected in male patients regarding the season/month of birth. After correction for multiple comparisons, the seasonal contrasts were no longer significant, whereas a subset of month-of-birth contrasts persisted.
CONCLUSIONS: Our results revealed a descriptive gradient where winter birth (specifically February) was associated with the shortest adult stature, a trend more pronounced among female patients. These findings suggest that winter birth is not only a risk factor for schizophrenia but may also impact anthropometry. Further research needs to examine potential etiologic causes for this association.