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DOI 10.1172/jci.insight.199443

Медицинская библиотека · JCI insight · 2025

Oral octanoylcarnitine alleviates exercise intolerance in mouse models of long-chain fatty acid oxidation disorders.

Brown Hilary K, Taylor Clare, Camden Andi, Lunsky Yona, Vigod Simone, Santiago Maria, Fung Kinwah, Cohen Eyal, Guttmann Astrid, Telner Deanna, Ray Joel, Zwicker Jennifer, Saunders Natasha

СтатьяПоддержка NIH: внешняя программаПеревод пока не подготовлен

Аннотация

OBJECTIVES

Preventive health care for children comprises routine well-child visits and immunizations. Women with physical, sensory, or intellectual or developmental disabilities tend to experience more barriers to preventive health care; yet it is unknown whether such barriers are observed among their young children.

METHODS

This population-based study in Ontario, Canada included children born between 2012 and 2019 whose mothers had a physical (n = 74 084), sensory (n = 26 532), or intellectual or developmental (n = 1391) disability, multiple disabilities (n = 5774), or no disability (n = 723 442). Primary outcomes were receipt of the recommended number of well-child visits and routine immunizations in the first 2 years. Secondary outcomes included receipt of the enhanced 18-month developmental assessment and any developmental screen. Relative risks (aRR) were generated using modified Poisson regression and adjusted for maternal sociodemographics and mental health and child sex.

RESULTS

Compared with children of mothers without disabilities, those whose mothers had intellectual or developmental disabilities were less likely to receive the recommended number of well-child visits (56.3% vs 63.2%; aRR 0.92, 95% confidence interval [CI] 0.88-0.97), routine immunizations (43.8% vs 53.7%; aRR 0.88, 95% CI 0.83-0.94), enhanced 18-month developmental assessment (52.3% vs 60.8%; aRR 0.92, 95% CI 0.88-0.97), or any developmental screen (54.9% vs 62.5%; aRR 0.94, 95% CI 0.90-0.99). Other disability groups did not experience such disparities.

CONCLUSIONS

There is a need to develop resources to improve access to preventive health care for young children of women with intellectual or developmental disabilities.

Для цитирования: Brown Hilary K, Taylor Clare, Camden Andi, Lunsky Yona, Vigod Simone, Santiago Maria, Fung Kinwah, Cohen Eyal, Guttmann Astrid, Telner Deanna, Ray Joel, Zwicker Jennifer, Saunders Natasha. Oral octanoylcarnitine alleviates exercise intolerance in mouse models of long-chain fatty acid oxidation disorders.. JCI insight. 2025. DOI: 10.1172/jci.insight.199443.

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