MedElevator Войти в исследования
← Поиск публикаций

DOI 10.1038/s41564-023-01589-3

Медицинская библиотека · Nature microbiology · 2024

Genome-wide association study identifies human genetic variants associated with fatal outcome from Lassa fever.

Kotliar Dylan, Raju Siddharth, Tabrizi Shervin, Odia Ikponmwosa, Goba Augustine, Momoh Mambu, Sandi John Demby, Nair Parvathy, Phelan Eric, Tariyal Ridhi, Eromon Philomena E, Mehta Samar, Robles-Sikisaka Refugio, Siddle Katherine J, Stremlau Matt, Jalloh Simbirie, Gire Stephen K, Winnicki Sarah, Chak Bridget, Schaffner Stephen F, Pauthner Matthias, Karlsson Elinor K, Chapin Sarah R, Kennedy Sharon G, Branco Luis M, Kanneh Lansana, Vitti Joseph J, Broodie Nisha, Gladden-Young Adrianne, Omoniwa Omowunmi, Jiang Pan-Pan, Yozwiak Nathan, Heuklom Shannon, Moses Lina M, Akpede George O, Asogun Danny A, Rubins Kathleen, Kales Susan, Happi Anise N, Iruolagbe Christopher O, Dic-Ijiewere Mercy, Iraoyah Kelly, Osazuwa Omoregie O, Okonkwo Alexander K, Kunz Stefan, McCormick Joseph B, Khan S Humarr, Honko Anna N, Lander Eric S, Oldstone Michael B A, Hensley Lisa, Folarin Onikepe A, Okogbenin Sylvanus A, Günther Stephan, Ollila Hanna M, Tewhey Ryan, Okokhere Peter O, Schieffelin John S, Andersen Kristian G, Reilly Steven K, Grant Donald S, Garry Robert F, Barnes Kayla G, Happi Christian T, Sabeti Pardis C

СтатьяПеревод в очереди

Аннотация

Infection with Lassa virus (LASV) can cause Lassa fever, a haemorrhagic illness with an estimated fatality rate of 29.7%, but causes no or mild symptoms in many individuals. Here, to investigate whether human genetic variation underlies the heterogeneity of LASV infection, we carried out genome-wide association studies (GWAS) as well as seroprevalence surveys, human leukocyte antigen typing and high-throughput variant functional characterization assays. We analysed Lassa fever susceptibility and fatal outcomes in 533 cases of Lassa fever and 1,986 population controls recruited over a 7 year period in Nigeria and Sierra Leone. We detected genome-wide significant variant associations with Lassa fever fatal outcomes near GRM7 and LIF in the Nigerian cohort. We also show that a haplotype bearing signatures of positive selection and overlapping LARGE1, a required LASV entry factor, is associated with decreased risk of Lassa fever in the Nigerian cohort but not in the Sierra Leone cohort. Overall, we identified variants and genes that may impact the risk of severe Lassa fever, demonstrating how GWAS can provide insight into viral pathogenesis.

Для цитирования: Kotliar Dylan, Raju Siddharth, Tabrizi Shervin, Odia Ikponmwosa, Goba Augustine, Momoh Mambu, Sandi John Demby, Nair Parvathy, Phelan Eric, Tariyal Ridhi, Eromon Philomena E, Mehta Samar, Robles-Sikisaka Refugio, Siddle Katherine J, Stremlau Matt, Jalloh Simbirie, Gire Stephen K, Winnicki Sarah, Chak Bridget, Schaffner Stephen F, Pauthner Matthias, Karlsson Elinor K, Chapin Sarah R, Kennedy Sharon G, Branco Luis M, Kanneh Lansana, Vitti Joseph J, Broodie Nisha, Gladden-Young Adrianne, Omoniwa Omowunmi, Jiang Pan-Pan, Yozwiak Nathan, Heuklom Shannon, Moses Lina M, Akpede George O, Asogun Danny A, Rubins Kathleen, Kales Susan, Happi Anise N, Iruolagbe Christopher O, Dic-Ijiewere Mercy, Iraoyah Kelly, Osazuwa Omoregie O, Okonkwo Alexander K, Kunz Stefan, McCormick Joseph B, Khan S Humarr, Honko Anna N, Lander Eric S, Oldstone Michael B A, Hensley Lisa, Folarin Onikepe A, Okogbenin Sylvanus A, Günther Stephan, Ollila Hanna M, Tewhey Ryan, Okokhere Peter O, Schieffelin John S, Andersen Kristian G, Reilly Steven K, Grant Donald S, Garry Robert F, Barnes Kayla G, Happi Christian T, Sabeti Pardis C. Genome-wide association study identifies human genetic variants associated with fatal outcome from Lassa fever.. Nature microbiology. 2024. DOI: 10.1038/s41564-023-01589-3.

Предметные рубрики MeSH

HumansLassa FeverGenome-Wide Association StudySeroepidemiologic StudiesLassa virusFeverHuman Genetics
Подготовка и перевод публикации
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…

История · было → стало

Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.

Тип публикации указан по данным источника. Уровень доказательности автоматически не присваивается.