Emerging infectious diseases · 2023
Influence of Landscape Patterns on Exposure to Lassa Fever Virus, Guinea.
СтатьяПоддержка исследования: вне правительства СШАПоддержка службы здравоохранения СШАНазвание и аннотация: Перевод в очереди
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Longet Stephanie, Leggio Cristina, Bore Joseph Akoi, Key Stephanie, Tipton Tom, Hall Yper, Koundouno Fara Raymond, Bower Hilary, Bhattacharyya Tapan, Magassouba N'Faly, Günther Stephan, Henao-Restrapo Ana-Maria, Rossman Jeremy S, Konde Mandy Kader, Fornace Kimberly, Carroll Miles W
Аннотация
Lassa fever virus (LASV) is the causative agent of Lassa fever, a disease endemic in West Africa. Exploring the relationships between environmental factors and LASV transmission across ecologically diverse regions can provide crucial information for the design of appropriate interventions and disease monitoring. We investigated LASV exposure in 2 ecologically diverse regions of Guinea. Our results showed that exposure to LASV was heterogenous between and within sites. LASV IgG seropositivity was 11.9% (95% CI 9.7%-14.5%) in a coastal study site in Basse-Guinée, but it was 59.6% (95% CI 55.5%-63.5%) in a forested study site located in Guinée Forestière. Seropositivity increased with age in the coastal site. We also found significant associations between exposure risk for LASV and landscape fragmentation in coastal and forested regions. Our study highlights the potential link between environmental change and LASV emergence and the urgent need for research on land management practices that reduce disease risks.