PM-01: Combined Factor V and Factor VIII Deficiency: A Case Report

INTRODUCTION : Combined factor V and factor VIII deficiency is a rare bleeding disorder due to autosomal recessive inheritance. Until now less than 150 cases reported worldwide. It is characterized by mild to moderate bleeding disorder and usually is asymptomatic. However, the risk of excessive bleeding following surgery, abortion and deliveries had been described. It should be suspected when both activated partial thromboplastin time and prothrombin time are persistently prolonged. Factor V and factor VIII levels ranges between 5 and 30 % in those reported cases. CASE REPORT : Here we report a patient who presented with cephalhaematoma at birth and found to have persistent abnormal coagulation screening tests and finally diagnosed as combined factor V and VIII deficiency. His elder brother also was suspected to have similar congenital deficiency; however he is asymptomatic since birth. CONCLUSION : Recognizing potential haemostatic defect in cephalhaematoma babies is an important step for early diagnosis and management of congenital bleeding disorder. PURPOSE : The aim of this study is to explore the level of parents’ knowledge regarding care of their premature baby at the Hospital Universiti Sains Malaysia. METHODOLOGY : This is a cross-sectional study conducted for a period of three months at the Hospital Universiti Sains Malaysia, Kelantan. Sixty respondents fulfilling the study criteria were recruited. Respondent’s level of knowledge was measured using questionnaire, which was adapted and composed from the High Risk Perinatal Home Care Manual using Likert scale. Statistical analyses performed were descriptive, independent t-test and ANOVA test. RESULTS : Results indicated that the knowledge of respondents regarding the care of premature baby was not very satisfactory. The respondent’s knowledge level regarding the causes for premature baby (12.4%), the importance of breast milk for premature baby (12.4%) and providing proper health care for preemies (17.3%). A part from that 16.1% respondent’s valued the issue of bonding during the hospitalization of their premature baby and 34.4% knew that immunization is very important for their premature baby. The respondents (7.4%) had knowledge about the physical developments of their premature baby and this result was significant when tested with ANOVA test (p= 0.045). CONCLUSION : The available data showed that many parents’ lacked knowledge regarding care of premature baby. Therefore it is very important for them to seek and update this information from the health professionals and the mass media. The findings from this study also provided more room for improvement among health professionals involved to address areas of less knowledge among parents’ in the future.