Tanu Garg, V. K. Yadav
Department of Pharmacology, People's College of Medical Sciences and Research Centre, Bhanpur, Bhopal (M.P.)
Objective: To evaluate the analgesic activity of resveratrol in different doses in animal models. Material and Methods: Albino mice of either sex weighing 20-30gms were selected for the study. Mice were assigned into 4 groups of 6 animals each. The control group received 0.9% normal saline (10 ml/kg), standard group received indomethacin (10 mg/kg) and test groups received resveratrol (50 mg/kg and 100 mg/kg). The drugs were given orally 1 hr prior to both the tests. The animals were tested for analgesia 30, 60, 90, 120 min after drug administration using tail flick method and 1% acetic acid was given intraperitoneally to induce writhing in the other method. Delay in the reaction time in tail flick method and decrease in total number of writhes in acetic acid induced writhing model denoted analgesic activity. Data analysis was done using one way ANOVA followed by Tuckey's HSD test. P < 0.05 was considered as statistically significant. Results: Resveratrol showed significant increase in reaction time at various time periods in tail flick method and showed significant decrease in the number of writhes in acetic acid induced writhing method. Conclusion: In the study, resveratrol exhibited analgesic activity in both thermal and chemical pain models in both the doses, and analgesic activity in higher dose (100 mg/kg) was comparable to standard drug.