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Войти в исследования Fatigue, sexual function and mood following treatment for haematological malignancy: the impact of mild Leydig cell dysfunction.
Аннотация
Fatigue, sexual dysfunction, anxiety and depression are all more common in patients who have previously been treated with cytotoxic chemotherapy and radiotherapy (XRT) for haematological malignancies. Following therapy, a significant proportion of men have biochemical evidence of Leydig cell dysfunction, defined by a raised luteinizing hormone level in the presence of a low/normal testosterone level. We postulated that mild testosterone deficiency may account for some of the long-term side-effects of treatment, and we have therefore assessed fatigue, mood and sexual function by questionnaire in 36 patients with Leydig cell dysfunction (group 1), and also in a group of 30 patients (group 2) with normal hormone levels who underwent the same treatment for cancer. There was no significant difference in anxiety and depression scores between the two groups although anxiety scores were higher than those previously reported for normal men. Eighty-seven per cent of group 2 were sexually active compared with only 69% of group 1 (P= 0.1), and patients in group 1 engaged less in sexual activity than those in group 2 (mean of 1.8 times per week compared with 3.2 times per week; P = 0.02) Fatigue scores were significantly higher in both groups compared with normal men, but there were no significant differences in any of the fatigue subscales between the two groups. We conclude that mild Leydig cell insufficiency following treatment with cytotoxic chemotherapy +/- XRT is not associated with higher levels of fatigue and anxiety but may result in reduced sexual function. These results do not provide a convincing argument that androgen replacement therapy is mandatory to improve quality of life in the majority of these patients, although it may be beneficial in a minority. To establish criteria for selection of patients for a trial of androgen therapy a randomized placebo-controlled study will be necessary.
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Selected References
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Aass N., Fosså S. D., Dahl A. A., Moe T. J. Prevalence of anxiety and depression in cancer patients seen at the Norwegian Radium Hospital. Eur J Cancer. 1997 Sep;33(10):1597–1604. doi: 10.1016/s0959-8049(97)00054-3.
Ahles T. A., Tope D. M., Furstenberg C., Hann D., Mills L. Psychologic and neuropsychologic impact of autologous bone marrow transplantation. J Clin Oncol. 1996 May;14(5):1457–1462. doi: 10.1200/JCO.1996.14.5.1457.
Arver S., Dobs A. S., Meikle A. W., Allen R. P., Sanders S. W., Mazer N. A. Improvement of sexual function in testosterone deficient men treated for 1 year with a permeation enhanced testosterone transdermal system. J Urol. 1996 May;155(5):1604–1608.
Berglund G., Bolund C., Fornander T., Rutqvist L. E., Sjödén P. O. Late effects of adjuvant chemotherapy and postoperative radiotherapy on quality of life among breast cancer patients. Eur J Cancer. 1991;27(9):1075–1081. doi: 10.1016/0277-5379(91)90295-o.
Bjordal K., Kaasa S., Mastekaasa A. Quality of life in patients treated for head and neck cancer: a follow-up study 7 to 11 years after radiotherapy. Int J Radiat Oncol Biol Phys. 1994 Mar 1;28(4):847–856. doi: 10.1016/0360-3016(94)90104-x.
Bloom J. R., Fobair P., Gritz E., Wellisch D., Spiegel D., Varghese A., Hoppe R. Psychosocial outcomes of cancer: a comparative analysis of Hodgkin's disease and testicular cancer. J Clin Oncol. 1993 May;11(5):979–988. doi: 10.1200/JCO.1993.11.5.979.
Burris A. S., Banks S. M., Carter C. S., Davidson J. M., Sherins R. J. A long-term, prospective study of the physiologic and behavioral effects of hormone replacement in untreated hypogonadal men. J Androl. 1992 Jul-Aug;13(4):297–304.
Carroll B. T., Kathol R. G., Noyes R., Jr, Wald T. G., Clamon G. H. Screening for depression and anxiety in cancer patients using the Hospital Anxiety and Depression Scale. Gen Hosp Psychiatry. 1993 Mar;15(2):69–74. doi: 10.1016/0163-8343(93)90099-a.
Devlen J., Maguire P., Phillips P., Crowther D. Psychological problems associated with diagnosis and treatment of lymphomas. II: Prospective study. Br Med J (Clin Res Ed) 1987 Oct 17;295(6604):955–957. doi: 10.1136/bmj.295.6604.955.
Fobair P., Hoppe R. T., Bloom J., Cox R., Varghese A., Spiegel D. Psychosocial problems among survivors of Hodgkin's disease. J Clin Oncol. 1986 May;4(5):805–814. doi: 10.1200/JCO.1986.4.5.805.
Greenberg D. B., Kornblith A. B., Herndon J. E., Zuckerman E., Schiffer C. A., Weiss R. B., Mayer R. J., Wolchok S. M., Holland J. C. Quality of life for adult leukemia survivors treated on clinical trials of Cancer and Leukemia Group B during the period 1971-1988: predictors for later psychologic distress. Cancer. 1997 Nov 15;80(10):1936–1944. doi: 10.1002/(sici)1097-0142(19971115)80:10<1936::aid-cncr10>3.0.co;2-z.
Hjermstad M. J., Kaasa S. Quality of life in adult cancer patients treated with bone marrow transplantation--a review of the literature. Eur J Cancer. 1995;31A(2):163–173. doi: 10.1016/0959-8049(94)00464-g.
Ibbotson T., Maguire P., Selby P., Priestman T., Wallace L. Screening for anxiety and depression in cancer patients: the effects of disease and treatment. Eur J Cancer. 1994;30A(1):37–40. doi: 10.1016/s0959-8049(05)80015-2.
Kornblith A. B., Anderson J., Cella D. F., Tross S., Zuckerman E., Cherin E., Henderson E. S., Canellos G. P., Kosty M. P., Cooper M. R. Comparison of psychosocial adaptation and sexual function of survivors of advanced Hodgkin disease treated by MOPP, ABVD, or MOPP alternating with ABVD. Cancer. 1992 Nov 15;70(10):2508–2516. doi: 10.1002/1097-0142(19921115)70:10<2508::aid-cncr2820701020>3.0.co;2-v.
Lisspers J., Nygren A., Söderman E. Hospital Anxiety and Depression Scale (HAD): some psychometric data for a Swedish sample. Acta Psychiatr Scand. 1997 Oct;96(4):281–286. doi: 10.1111/j.1600-0447.1997.tb10164.x.
Loge J. H., Abrahamsen A. F., Ekeberg O., Hannisdal E., Kaasa S. Psychological distress after cancer cure: a survey of 459 Hodgkin's disease survivors. Br J Cancer. 1997;76(6):791–796. doi: 10.1038/bjc.1997.464.
Marks D. I., Friedman S. H., Delli Carpini L., Nezu C. M., Nezu A. M. A prospective study of the effects of high-dose chemotherapy and bone marrow transplantation on sexual function in the first year after transplant. Bone Marrow Transplant. 1997 Apr;19(8):819–822. doi: 10.1038/sj.bmt.1700750.
Moorey S., Greer S., Watson M., Gorman C., Rowden L., Tunmore R., Robertson B., Bliss J. The factor structure and factor stability of the hospital anxiety and depression scale in patients with cancer. Br J Psychiatry. 1991 Feb;158:255–259. doi: 10.1192/bjp.158.2.255.
Razavi D., Delvaux N., Farvacques C., Robaye E. Screening for adjustment disorders and major depressive disorders in cancer in-patients. Br J Psychiatry. 1990 Jan;156:79–83. doi: 10.1192/bjp.156.1.79.
Smets E. M., Garssen B., Cull A., de Haes J. C. Application of the multidimensional fatigue inventory (MFI-20) in cancer patients receiving radiotherapy. Br J Cancer. 1996 Jan;73(2):241–245. doi: 10.1038/bjc.1996.42.
Smets E. M., Garssen B., Schuster-Uitterhoeve A. L., de Haes J. C. Fatigue in cancer patients. Br J Cancer. 1993 Aug;68(2):220–224. doi: 10.1038/bjc.1993.319.
Smets E. M., Visser M. R., Willems-Groot A. F., Garssen B., Schuster-Uitterhoeve A. L., de Haes J. C. Fatigue and radiotherapy: (B) experience in patients 9 months following treatment. Br J Cancer. 1998 Oct;78(7):907–912. doi: 10.1038/bjc.1998.600.
Wang C., Alexander G., Berman N., Salehian B., Davidson T., McDonald V., Steiner B., Hull L., Callegari C., Swerdloff R. S. Testosterone replacement therapy improves mood in hypogonadal men--a clinical research center study. J Clin Endocrinol Metab. 1996 Oct;81(10):3578–3583. doi: 10.1210/jcem.81.10.8855804.
Zigmond A. S., Snaith R. P. The hospital anxiety and depression scale. Acta Psychiatr Scand. 1983 Jun;67(6):361–370. doi: 10.1111/j.1600-0447.1983.tb09716.x.
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