MedElevator Войти в исследования
← Поиск публикаций

DOI 10.1016/j.ccell.2026.03.003

Медицинская библиотека · Cancer cell · 2026

Cancer type-specific variation in patterns of driver alterations across 50,000 tumors.

Bandlamudi Chaitanya, Muldoon Daniel, de Bruijn Ino, Zhang Mingxuan, Gormally Michael V, Harrold Emily C, Nandakumar Subhiksha, Smith Shaleigh A, Jeng Mark Y, Woods Sydney, Arora Kanika, Chatila Walid K, Nguyen Bastien, Walch Henry, Woo Jun, Bielski Craig M, Fong Christopher, Tran Thinh N, Zhao Gaofei, Mehine Miika, Perry Maria A, Tischfield Sam E, Richards Allison L, Rajendran Suraj, Zhang Hongxin, Kreitzer Christoph K, Shah Ronak, Huq Risha, Galle Jesse, Alano Tina, Madupuri Ramyasree, Kundra Ritika, Jee Justin, Pichotta Karl, Waters Michele, Hickman Richard A, Dermawan Josephine K, Chen Jie-Fu, Safonov Anton, Stopsack Konrad H, Kotecha Ritesh R, Rizvi Hira A, Friedman Claire F, Razavi Pedram, Rosen Ezra, Murciano-Goroff Yonina R, Morris Luc G T, Fagin James A, Mellinghoff Ingo K, Chi Ping, Shukla Neerav N, Schoenfeld Adam J, Riely Gregory J, Rudin Charles M, Drilon Alexander, Lee Jake June-Koo, Al-Ahmadie Hikmat A, Iyer Gopa, Varghese Anna M, O'Reilly Eileen M, Stadler Zsofia K, Robson Mark E, Reznik Ed, Gao JianJiong, Mandelker Diana, Ostrovnaya Irina, Rana Satshil, Jayakumaran Gowtham, Bowman Anita, Mohanty Abhinita, Balakrishnan Anoop Rema, Syed Aijazuddin, Ptashkin Ryan N, Casanova-Murphy Jacklyn, Chakravarty Debyani, Benayed Ryma, Arcila Maria E, Chandarlapaty Sarat, Yu Helena A, Rosen Neal, Donoghue Mark T A, Klebanoff Christopher A, Yaeger Rona, Brannon A Rose, Zehir Ahmet, Ladanyi Marc, Schultz Nikolaus, Solit David B, Berger Michael F

СтатьяПеревод в очереди

Аннотация

The oncogenic impact of somatic driver alterations is shaped by tissue context. Classifying alterations by cancer type and evaluating their context-specific properties requires large cohorts of genomically profiled and clinically annotated tumors. Here, we define cancer type-specific patterns of driver alterations, including 164 newly identified hotspots, in 54,331 tumors from 48,179 patients spanning 448 histological cancer subtypes. One-third of all drivers arose in non-canonical contexts and exhibited distinct features, including increased subclonality, later emergence, and divergent biological properties. Within cancer types, gene fusions and other distinct patterns of co-occurring drivers are indicative of earlier age of disease onset. We also identify ancestry-specific differences in human leukocyte antigen (HLA)-restricted driver neoantigens affecting T cell receptor therapy eligibility, and demonstrate cancer-type-specific patterns of intrinsic resistance via somatic HLA loss. Our findings highlight that functional roles of driver alterations depend on the cancer types and clinical contexts in which they arise.

Для цитирования: Bandlamudi Chaitanya, Muldoon Daniel, de Bruijn Ino, Zhang Mingxuan, Gormally Michael V, Harrold Emily C, Nandakumar Subhiksha, Smith Shaleigh A, Jeng Mark Y, Woods Sydney, Arora Kanika, Chatila Walid K, Nguyen Bastien, Walch Henry, Woo Jun, Bielski Craig M, Fong Christopher, Tran Thinh N, Zhao Gaofei, Mehine Miika, Perry Maria A, Tischfield Sam E, Richards Allison L, Rajendran Suraj, Zhang Hongxin, Kreitzer Christoph K, Shah Ronak, Huq Risha, Galle Jesse, Alano Tina, Madupuri Ramyasree, Kundra Ritika, Jee Justin, Pichotta Karl, Waters Michele, Hickman Richard A, Dermawan Josephine K, Chen Jie-Fu, Safonov Anton, Stopsack Konrad H, Kotecha Ritesh R, Rizvi Hira A, Friedman Claire F, Razavi Pedram, Rosen Ezra, Murciano-Goroff Yonina R, Morris Luc G T, Fagin James A, Mellinghoff Ingo K, Chi Ping, Shukla Neerav N, Schoenfeld Adam J, Riely Gregory J, Rudin Charles M, Drilon Alexander, Lee Jake June-Koo, Al-Ahmadie Hikmat A, Iyer Gopa, Varghese Anna M, O'Reilly Eileen M, Stadler Zsofia K, Robson Mark E, Reznik Ed, Gao JianJiong, Mandelker Diana, Ostrovnaya Irina, Rana Satshil, Jayakumaran Gowtham, Bowman Anita, Mohanty Abhinita, Balakrishnan Anoop Rema, Syed Aijazuddin, Ptashkin Ryan N, Casanova-Murphy Jacklyn, Chakravarty Debyani, Benayed Ryma, Arcila Maria E, Chandarlapaty Sarat, Yu Helena A, Rosen Neal, Donoghue Mark T A, Klebanoff Christopher A, Yaeger Rona, Brannon A Rose, Zehir Ahmet, Ladanyi Marc, Schultz Nikolaus, Solit David B, Berger Michael F. Cancer type-specific variation in patterns of driver alterations across 50,000 tumors.. Cancer cell. 2026. DOI: 10.1016/j.ccell.2026.03.003.

Предметные рубрики MeSH

HumansNeoplasmsHLA AntigensMutation
Подготовка и перевод публикации
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…

История · было → стало

Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.

Тип публикации указан по данным источника. Уровень доказательности автоматически не присваивается.