[Anticancer activity of Crocodylus siamensis blood in vitro and in vivo].

OBJECTIVE

To study the anticancer effects of the blood of Crocodylus siamensis in vitro and in vivo.

METHODS

The inhibitory effects of serum and plasma of Crocodylus siamensis on proliferation of HepG2, BGC823, HeLa and SKOV3 cell were measured by MTT assay. The mouse S180 tumor model was used to evaluate the anti-tumor effect in vivo.

RESULTS

High dosage serum and plasma of Crocodylus siamensis could inhibit the proliferation of HepG2, BGC823, HeLa and SKOV3 cell. The tumor inhibitory rate of high dosage blood of Crocodylus siamensis on S180 tumor was up to 57.55%.

CONCLUSION

The blood of breeding Crocodylus siamensis has anticancer activity.