Revista da Sociedade Brasileira de Medicina Tropical · 2022
Endophytic fungus Phomopsis sp. as a source of 3-nitropropionic acid with larvicidal activity against Aedes aegypti (Linnaeus 1762, Diptera: Culicidae).
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Garcia Armando da Costa, Menezes Júnior Orivaldo Teixeira de, Mariano Lissa Apolonia, Santiago Letícia Corrêa, Araújo Ângela Regina, Monfardini Julia Dietsche, Simões Rejane de Castro, Oliveira André Correa de, Roque Rosemary Aparecida, Tadei Wanderli Pedro, Teles Helder Lopes, Oliveira Camila Martins de
Аннотация
BACKGROUND: Aedes aegypti is the primary vector of viruses, such as Zika, chikungunya, yellow fever, and dengue. In this context, a biomonitored chemical study was conducted to evaluate the activity of the crude extract of the endophytic fungus Phomopsis sp. against the larvae of Aedes aegypti.
METHODS: Crude extract, fractions, and isolated substances were evaluated in in-vitro assays against third-stage larvae of Aedes aegypti.
RESULTS: We isolated 3-nitropropionic acid with an LC50 of 15.172 ppm and LC90 of 18.178 ppm after 24 hours of larval exposure.
CONCLUSIONS: The results indicated that 3-nitropropionic acid exerted larvicidal activity.
METHODS: Crude extract, fractions, and isolated substances were evaluated in in-vitro assays against third-stage larvae of Aedes aegypti.
RESULTS: We isolated 3-nitropropionic acid with an LC50 of 15.172 ppm and LC90 of 18.178 ppm after 24 hours of larval exposure.
CONCLUSIONS: The results indicated that 3-nitropropionic acid exerted larvicidal activity.