Clinical study of mezlocillin for the treatment and prevention of postoperative obstetric and gynecological infections.

Twenty-one women were given mezlocillin for the treatment or prevention of infections after obstetric and gynecological surgery. Ten women had active infections caused by Escherichia coli, Klebsiella species, Proteus mirabilis, Pseudomonas aeruginosa, or Streptococcus faecalis. They had a 90% rate of recovery after an average of seven days of treatment with 6 to 15 gm/day of mezlocillin. The other 11 women were given mezlocillin prophylactically, 2 gm every 12 hours for seven days. All had good postoperative courses without complications caused by infections. Among both groups only three adverse reactions occurred, two instances of rash and one case of moderate diarrhea. All resolved spontaneously without discontinuation of treatment.