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DOI 10.1056/nejmoa1804498

Медицинская библиотека · The New England journal of medicine · 2018

Genomic Analysis of Lassa Virus during an Increase in Cases in Nigeria in 2018.

Siddle Katherine J, Eromon Philomena, Barnes Kayla G, Mehta Samar, Oguzie Judith U, Odia Ikponmwosa, Schaffner Stephen F, Winnicki Sarah M, Shah Rickey R, Qu James, Wohl Shirlee, Brehio Patrick, Iruolagbe Christopher, Aiyepada John, Uyigue Eghosa, Akhilomen Patience, Okonofua Grace, Ye Simon, Kayode Tolulope, Ajogbasile Fehintola, Uwanibe Jessica, Gaye Amy, Momoh Mambu, Chak Bridget, Kotliar Dylan, Carter Amber, Gladden-Young Adrianne, Freije Catherine A, Omoregie Omigie, Osiemi Blessing, Muoebonam Ekene B, Airende Michael, Enigbe Rachael, Ebo Benevolence, Nosamiefan Iguosadolo, Oluniyi Paul, Nekoui Mahan, Ogbaini-Emovon Ephraim, Garry Robert F, Andersen Kristian G, Park Daniel J, Yozwiak Nathan L, Akpede George, Ihekweazu Chikwe, Tomori Oyewale, Okogbenin Sylvanus, Folarin Onikepe A, Okokhere Peter O, MacInnis Bronwyn L, Sabeti Pardis C, Happi Christian T

СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАПеревод в очереди

Аннотация

During 2018, an unusual increase in Lassa fever cases occurred in Nigeria, raising concern among national and international public health agencies. We analyzed 220 Lassa virus genomes from infected patients, including 129 from the 2017-2018 transmission season, to understand the viral populations underpinning the increase. A total of 14 initial genomes from 2018 samples were generated at Redeemer's University in Nigeria, and the findings were shared with the Nigerian Center for Disease Control in real time. We found that the increase in cases was not attributable to a particular Lassa virus strain or sustained by human-to-human transmission. Instead, the data were consistent with ongoing cross-species transmission from local rodent populations. Phylogenetic analysis also revealed extensive viral diversity that was structured according to geography, with major rivers appearing to act as barriers to migration of the rodent reservoir.

Для цитирования: Siddle Katherine J, Eromon Philomena, Barnes Kayla G, Mehta Samar, Oguzie Judith U, Odia Ikponmwosa, Schaffner Stephen F, Winnicki Sarah M, Shah Rickey R, Qu James, Wohl Shirlee, Brehio Patrick, Iruolagbe Christopher, Aiyepada John, Uyigue Eghosa, Akhilomen Patience, Okonofua Grace, Ye Simon, Kayode Tolulope, Ajogbasile Fehintola, Uwanibe Jessica, Gaye Amy, Momoh Mambu, Chak Bridget, Kotliar Dylan, Carter Amber, Gladden-Young Adrianne, Freije Catherine A, Omoregie Omigie, Osiemi Blessing, Muoebonam Ekene B, Airende Michael, Enigbe Rachael, Ebo Benevolence, Nosamiefan Iguosadolo, Oluniyi Paul, Nekoui Mahan, Ogbaini-Emovon Ephraim, Garry Robert F, Andersen Kristian G, Park Daniel J, Yozwiak Nathan L, Akpede George, Ihekweazu Chikwe, Tomori Oyewale, Okogbenin Sylvanus, Folarin Onikepe A, Okokhere Peter O, MacInnis Bronwyn L, Sabeti Pardis C, Happi Christian T. Genomic Analysis of Lassa Virus during an Increase in Cases in Nigeria in 2018.. The New England journal of medicine. 2018. DOI: 10.1056/nejmoa1804498.

Предметные рубрики MeSH

AdolescentAdultAnimalsBayes TheoremDisease ReservoirsFemaleGenetic VariationGenome, ViralHumansLassa FeverLassa virusMaleMarkov ChainsMiddle AgedNigeriaPhylogenyPhylogeographyRNA, ViralRodentiaSequence Analysis, RNAZoonoses
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