Understanding Sabiá virus infections (Brazilian mammarenavirus).
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
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Nastri Ana Catharina, Duarte-Neto Amaro Nunes, Casadio Luciana Vilas Boas, Souza William Marciel de, Claro Ingra M, Manuli Erika R, Selegatto Gloria, Salomão Matias C, Fialkovitz Gabriel, Taborda Mariane, Almeida Bianca Leal de, Magri Marcello C, Guedes Ana Rúbia, Perdigão Neto Lauro Vieira, Sataki Fatima Mitie, Guimarães Thais, Mendes-Correa Maria Cassia, Tozetto-Mendoza Tania R, Fumagalli Marcilio Jorge, Ho Yeh-Li, Maia da Silva Camila Alves, Coletti Thaís M, Goes de Jesus Jaqueline, Romano Camila M, Hill Sarah C, Pybus Oliver, Rebello Pinho João Renato, Ledesma Felipe Lourenço, Casal Yuri R, Kanamura Cristina T, Tadeu de Araújo Leonardo José, Ferreira Camila Santos da Silva, Guerra Juliana Mariotti, Figueiredo Luiz Tadeu Moraes, Dolhnikoff Marisa, Faria Nuno R, Sabino Ester C, Alves Venâncio Avancini Ferreira, Levin Anna S
Аннотация
METHODS: We diagnosed two new cases of SABV infection using metagenomics in patients thought to have severe yellow fever and described new features of histopathological findings.
RESULTS: We characterized clinical manifestations, histopathology and analyzed possible nosocomial transmission. Patients presented with hepatitis, bleeding, neurological alterations and died. We traced twenty-nine hospital contacts and evaluated them clinically and by RT-PCR and neutralizing antibodies. Autopsies uncovered unique features on electron microscopy, such as hepatocyte "pinewood knot" lesions. Although previous reports with similar New-World arenavirus had nosocomial transmission, our data did not find any case in contact tracing.
CONCLUSIONS: Although an apparent by rare, Brazilian mammarenavirus infection is an etiology for acute hemorrhagic fever syndrome. The two fatal cases had peculiar histopathological findings not previously described. The virological diagnosis was possible only by contemporary techniques such as metagenomic assays. We found no subsequent infections when we used serological and molecular tests to evaluate close contacts.