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Войти в исследования Infective Endocarditis Following Transcatheter Aortic Valve Replacement: Comparison of Balloon- Versus Self-Expandable Valves.
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Regueiro Ander, Linke Axel, Latib Azeem, Ihlemann Nikolaj, Urena Marina, Walther Thomas, Husser Oliver, Herrmann Howard, Nombela-Franco Luis, Cheema Asim, Le Breton Hervé, Stortecky Stefan, Kapadia Samir, Bartorelli Antonio, Sinning Jan Malte, Amat-Santos Ignacio, Munoz-Garcia Antonio, Lerakis Stamatios, Gutíerrez-Ibanes Enrique, Abdel-Wahab Mohamed, Tchetche Didier, Testa Luca, Eltchaninoff Helene, Livi Ugolino, Castillo Juan Carlos, Jilaihawi Hasan, Webb John, Barbanti Marco, Kodali Susheel, de Brito Jr Fabio, Ribeiro Henrique, Miceli Antonio, Fiorina Claudia, Actis Dato Guglielmo Mario, Rosato Francesco, Serra Vicenç, Masson Jean-Bernard, Wijeysundera Harindra, Mangione Jose, Ferreira Maria-Cristina, Lima Valter, Carvalho Luis, Abizaid Alexandre, Marino Marcos, Esteves Vinicius, Andrea Julio, Messika-Zeitoun David, Himbert Dominique, Kim Won-Keun, Pellegrini Costanza, Auffret Vincent, Nietlispach Fabian, Pilgrim Thomas, Durand Eric, Lisko John, Makkar Raj, Lemos Pedro, Leon Martin, Puri Rishi, San Roman Alberto, Vahanian Alec, Søndergaard Lars, Mangner Norman, Rodés-Cabau Josep
Аннотация
METHODS: Data from the multicenter Infectious Endocarditis After TAVR International Registry was used to compare IE patients with BEV versus SEV.
RESULTS: A total of 245 patients with IE post-TAVR were included (SEV, 47%; BEV, 53%). The timing between TAVR and IE was similar between groups (SEV, 5.5 [1.2-15] months versus BEV, 5.3 [1.7-11.4] months; P=0.89). Enterococcal IE was more frequent in the SEV group (36.5% versus 15.4%; P<0.01), and vegetation location differed according to valve type (stent frame, SEV, 18.6%; BEV, 6.9%; P=0.01; valve leaflet, SEV, 23.9%; BEV, 38.5%; P=0.01). BEV recipients had a higher rate of stroke/systemic embolism (20.0% versus 8.7%, adjusted OR: 2.46, 95% CI: 1.04-5.82, P=0.04). Surgical explant of the transcatheter valve (SEV, 8.7%; BEV, 13.8%; P=0.21), and in-hospital death at the time of IE episode (SEV, 35.6%; BEV, 37.7%; P=0.74) were similar between groups. After a mean follow-up of 13±12 months, 59.1% and 54.6% of the SEV and BEV recipients, respectively, had died (P=0.66).
CONCLUSIONS: The characteristics of IE post-TAVR, including microorganism type, vegetation location, and embolic complications but not early or late mortality, differed according to valve type. These results may help to guide the diagnosis and management of IE and inform future research studies in the field.