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DOI 10.1016/j.cell.2015.07.020

Медицинская библиотека · Cell · 2015

Clinical Sequencing Uncovers Origins and Evolution of Lassa Virus.

Andersen Kristian G, Shapiro B Jesse, Matranga Christian B, Sealfon Rachel, Lin Aaron E, Moses Lina M, Folarin Onikepe A, Goba Augustine, Odia Ikponmwonsa, Ehiane Philomena E, Momoh Mambu, England Eleina M, Winnicki Sarah, Branco Luis M, Gire Stephen K, Phelan Eric, Tariyal Ridhi, Tewhey Ryan, Omoniwa Omowunmi, Fullah Mohammed, Fonnie Richard, Fonnie Mbalu, Kanneh Lansana, Jalloh Simbirie, Gbakie Michael, Saffa Sidiki, Karbo Kandeh, Gladden Adrianne D, Qu James, Stremlau Matthew, Nekoui Mahan, Finucane Hilary K, Tabrizi Shervin, Vitti Joseph J, Birren Bruce, Fitzgerald Michael, McCowan Caryn, Ireland Andrea, Berlin Aaron M, Bochicchio James, Tazon-Vega Barbara, Lennon Niall J, Ryan Elizabeth M, Bjornson Zach, Milner Danny A, Lukens Amanda K, Broodie Nisha, Rowland Megan, Heinrich Megan, Akdag Marjan, Schieffelin John S, Levy Danielle, Akpan Henry, Bausch Daniel G, Rubins Kathleen, McCormick Joseph B, Lander Eric S, Günther Stephan, Hensley Lisa, Okogbenin Sylvanus, Viral Hemorrhagic Fever Consortium, Schaffner Stephen F, Okokhere Peter O, Khan S Humarr, Grant Donald S, Akpede George O, Asogun Danny A, Gnirke Andreas, Levin Joshua Z, Happi Christian T, Garry Robert F, Sabeti Pardis C

СтатьяПоддержка NIH: внешняя программаПеревод в очереди

Аннотация

The 2013-2015 West African epidemic of Ebola virus disease (EVD) reminds us of how little is known about biosafety level 4 viruses. Like Ebola virus, Lassa virus (LASV) can cause hemorrhagic fever with high case fatality rates. We generated a genomic catalog of almost 200 LASV sequences from clinical and rodent reservoir samples. We show that whereas the 2013-2015 EVD epidemic is fueled by human-to-human transmissions, LASV infections mainly result from reservoir-to-human infections. We elucidated the spread of LASV across West Africa and show that this migration was accompanied by changes in LASV genome abundance, fatality rates, codon adaptation, and translational efficiency. By investigating intrahost evolution, we found that mutations accumulate in epitopes of viral surface proteins, suggesting selection for immune escape. This catalog will serve as a foundation for the development of vaccines and diagnostics. VIDEO ABSTRACT.

Для цитирования: Andersen Kristian G, Shapiro B Jesse, Matranga Christian B, Sealfon Rachel, Lin Aaron E, Moses Lina M, Folarin Onikepe A, Goba Augustine, Odia Ikponmwonsa, Ehiane Philomena E, Momoh Mambu, England Eleina M, Winnicki Sarah, Branco Luis M, Gire Stephen K, Phelan Eric, Tariyal Ridhi, Tewhey Ryan, Omoniwa Omowunmi, Fullah Mohammed, Fonnie Richard, Fonnie Mbalu, Kanneh Lansana, Jalloh Simbirie, Gbakie Michael, Saffa Sidiki, Karbo Kandeh, Gladden Adrianne D, Qu James, Stremlau Matthew, Nekoui Mahan, Finucane Hilary K, Tabrizi Shervin, Vitti Joseph J, Birren Bruce, Fitzgerald Michael, McCowan Caryn, Ireland Andrea, Berlin Aaron M, Bochicchio James, Tazon-Vega Barbara, Lennon Niall J, Ryan Elizabeth M, Bjornson Zach, Milner Danny A, Lukens Amanda K, Broodie Nisha, Rowland Megan, Heinrich Megan, Akdag Marjan, Schieffelin John S, Levy Danielle, Akpan Henry, Bausch Daniel G, Rubins Kathleen, McCormick Joseph B, Lander Eric S, Günther Stephan, Hensley Lisa, Okogbenin Sylvanus, Viral Hemorrhagic Fever Consortium, Schaffner Stephen F, Okokhere Peter O, Khan S Humarr, Grant Donald S, Akpede George O, Asogun Danny A, Gnirke Andreas, Levin Joshua Z, Happi Christian T, Garry Robert F, Sabeti Pardis C. Clinical Sequencing Uncovers Origins and Evolution of Lassa Virus.. Cell. 2015. DOI: 10.1016/j.cell.2015.07.020.

Предметные рубрики MeSH

Africa, WesternAnimalsBiological EvolutionDisease ReservoirsEbolavirusGenetic VariationGenome, ViralGlycoproteinsHemorrhagic Fever, EbolaHumansLassa FeverLassa virusMurinaeMutationNigeriaRNA, ViralViral ProteinsZoonoses
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