The Thoracic and cardiovascular surgeon · 2015
One-Year Clinical Outcome after Left Ventricular Assist Device Malfunction.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Oezpeker U Cenk, Zittermann Armin, Erkilet Guelsuem, Schulz Uwe, Ensminger Stephan, Gummert Jan F, Morshuis Michiel
Аннотация
BACKGROUND: Left ventricular assist device (LVAD) implants bear the risk of driveline/device infections and technical failures.
METHODS: We assessed clinical outcome in LVAD patients with device-related complications. Group 1 (n = 12) received device exchange (DEx) as destination therapy (DT), group 2 (n = 15) received DEx as a bridge to transplant (BTT), group 3 (n = 34) was allocated to receive high-urgency (HU) heart transplantation (HTx), and group 4 (n = 27) had device-related complications that could only be solved by HTx. Primary endpoint was 1-year overall survival.
RESULTS: Age and Simplified Acute Physiology Score II differed significantly between groups and were highest in group 1, lowest in group 3. One-year survival in groups 1 to 4 was 66.7, 60.0, 82.4, and 70.4% (p = 0.30). Covariate-adjusted odds ratio of 1-year survival (reference: group 1) was for group 2 = 1.52 (95% confidence interval [CI]: 0.42-5.57), for group 3 = 1.13 (95% CI: 0.28-4.56), and for group 4 = 1.89 (95% CI: 0.51-7.04; p for trend 0.70). Clinical complications (need of mechanical ventilator support, extracorporeal circulatory membrane oxygenation (ECMO) implants, kidney/liver dialysis) were comparable between groups.
CONCLUSION: Data indicate similar 1-year clinical outcomes in LVAD patients with device-related complications receiving DEx or HTx.
METHODS: We assessed clinical outcome in LVAD patients with device-related complications. Group 1 (n = 12) received device exchange (DEx) as destination therapy (DT), group 2 (n = 15) received DEx as a bridge to transplant (BTT), group 3 (n = 34) was allocated to receive high-urgency (HU) heart transplantation (HTx), and group 4 (n = 27) had device-related complications that could only be solved by HTx. Primary endpoint was 1-year overall survival.
RESULTS: Age and Simplified Acute Physiology Score II differed significantly between groups and were highest in group 1, lowest in group 3. One-year survival in groups 1 to 4 was 66.7, 60.0, 82.4, and 70.4% (p = 0.30). Covariate-adjusted odds ratio of 1-year survival (reference: group 1) was for group 2 = 1.52 (95% confidence interval [CI]: 0.42-5.57), for group 3 = 1.13 (95% CI: 0.28-4.56), and for group 4 = 1.89 (95% CI: 0.51-7.04; p for trend 0.70). Clinical complications (need of mechanical ventilator support, extracorporeal circulatory membrane oxygenation (ECMO) implants, kidney/liver dialysis) were comparable between groups.
CONCLUSION: Data indicate similar 1-year clinical outcomes in LVAD patients with device-related complications receiving DEx or HTx.
Предметные рубрики MeSH
APACHEAdultAgedChi-Square DistributionDevice RemovalFemaleHeart FailureHeart TransplantationHeart-Assist DevicesHumansKaplan-Meier EstimateMaleMedical RecordsMiddle AgedOdds RatioPredictive Value of TestsProportional Hazards ModelsProsthesis DesignProsthesis FailureRetrospective StudiesRisk FactorsTime FactorsTreatment OutcomeVentricular Function, LeftWaiting Lists