Recent Proceedings of Advanced Electrochemiluminescence Imaging Technology and Applications in Accurate Analysis.

Electrochemiluminescence (ECL) imaging has emerged as a highly sensitive and spatially resolved bioanalytical technique that bridges electrochemical control and optical microscopy. With its unique surface-confined emission, minimal background noise, and tunable activation, ECL imaging offers distinct advantages over fluorescence and chemiluminescence, especially for cellular and single-particle analysis. In this review, advanced strategies and wireless, multiplexed, and high-throughput bioimaging platforms, such as bipolar electrochemistry, single-electrode electrochemical system, and multielectrode array are summarized. Applications of ECL imaging methods in the single-cell analysis, nanoparticle electrocatalysis studies, intracellular and in vivo detection, and high-resolution bioassays are described in detail. This review has comprehensively outlined recent progress in these advanced technologies and presenting some emerging tools such as miniaturized devices, wireless energy transmission, and next-generation materials driving the transformation of ECL imaging into a robust platform for diagnostics and research. This work has not only summarized past progress but also explored future breakthroughs in precision diagnostics and electrochemical microscopy.