Viruses · 2021
Real-Time Genomic Surveillance during the 2021 Re-Emergence of the Yellow Fever Virus in Rio Grande do Sul State, Brazil.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Andrade Miguel de S, Campos Fabrício S, Campos Aline A S, Abreu Filipe V S, Melo Fernando L, Sevá Anaiá da P, Cardoso Jader da C, Dos Santos Edmilson, Born Lucas C, Silva Cláudia M D da, Müller Nicolas F D, Oliveira Cirilo H de, Silva Alex J J da, Simonini-Teixeira Danilo, Bernal-Valle Sofía, Mares-Guia Maria A M M, Albuquerque George R, Romano Alessandro P M, Franco Ana C, Ribeiro Bergmann M, Roehe Paulo M, Almeida Marco A B de
Аннотация
The 2021 re-emergence of yellow fever in non-human primates in the state of Rio Grande do Sul (RS), southernmost Brazil, resulted in the death of many howler monkeys (genus Alouatta) and led the state to declare a Public Health Emergency of State Importance, despite no human cases reported. In this study, near-complete genomes of yellow fever virus (YFV) recovered from the outbreak were sequenced and examined aiming at a better understanding of the phylogenetic relationships and the spatio-temporal dynamics of the virus distribution. Our results suggest that the most likely sequence of events involved the reintroduction of YFV from the state of São Paulo to RS through the states of Paraná and Santa Catarina, by the end of 2020. These findings reinforce the role of genomic surveillance in determining the pathways of distribution of the virus and in providing references for the implementation of preventive measures for populations in high risk areas.