Circulation journal : official journal of the Japanese Circulation Society · 2010
Three-month dual antiplatelet therapy after implantation of zotarolimus-eluting stents: the DATE (Duration of Dual Antiplatelet Therapy AfterImplantation of Endeavor Stent) registry.
СтатьяМногоцентровое исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Hahn Joo-Yong, Song Young Bin, Choi Jin-Ho, Choi Sung-Hyuk, Lee Sung Yun, Park Hun Sik, Hur Seung Ho, Lee Sahng, Han Kyoo-Rok, Rha Seung-Woon, Cho Byung Ryul, Park Jong-Sun, Yoon Junghan, Lim Do Sun, Lee Sang Hoon, Gwon Hyeon-Cheol, DATE Registry Investigators
Аннотация
BACKGROUND: The optimal duration of dual antiplatelet therapy remains controversial.
METHODS AND RESULTS: Between December 2006 and March 2008, 823 patients were enrolled in a prospective multicenter registry for 3-month dual antiplatelet therapy (aspirin 100-200mg+clopidogrel 75 mg daily) followed by aspirin mono-therapy after zotarolimus-eluting stents (ZES). Major exclusion criteria were: cardiogenic shock, stent thrombosis (ST)-segment elevation myocardial infarction (MI) within 48h, previous drug-eluting stent implantation, severe left ventricular dysfunction, bifurcation lesions requiring 2-stenting, left main and graft lesions. The primary outcome was a composite of cardiac death, MI, or ST at 1 year. The median duration of dual antiplatelet therapy was 95 days (interquartile range 90-101). At 1 year, 3 patients (0.4%) had cardiac deaths, 3 patients (0.4%) had MI, and 4 patients (0.5%) had definite or probable ST, leading to the primary outcome in 5 patients (0.6%). Death, MI, or any revascularization occurred in 68 patients (8.3%). Among patients who were event-free at 3 months (n=812), clopidogrel was discontinued at 3 months in 661 patients and was continued for longer than 3 months in 151 patients. Discontinuation of clopidogrel at 3 months did not increase the primary outcome (HR 0.90; 95%CI, 0.09-9.02), death, MI, or any revascularization (HR 0.89; 95%CI, 0.48-1.67) after adjustment for the propensity score.
CONCLUSIONS: Three-month dual antiplatelet therapy seems to be feasible after ZES implantation in relatively low-risk patients.
METHODS AND RESULTS: Between December 2006 and March 2008, 823 patients were enrolled in a prospective multicenter registry for 3-month dual antiplatelet therapy (aspirin 100-200mg+clopidogrel 75 mg daily) followed by aspirin mono-therapy after zotarolimus-eluting stents (ZES). Major exclusion criteria were: cardiogenic shock, stent thrombosis (ST)-segment elevation myocardial infarction (MI) within 48h, previous drug-eluting stent implantation, severe left ventricular dysfunction, bifurcation lesions requiring 2-stenting, left main and graft lesions. The primary outcome was a composite of cardiac death, MI, or ST at 1 year. The median duration of dual antiplatelet therapy was 95 days (interquartile range 90-101). At 1 year, 3 patients (0.4%) had cardiac deaths, 3 patients (0.4%) had MI, and 4 patients (0.5%) had definite or probable ST, leading to the primary outcome in 5 patients (0.6%). Death, MI, or any revascularization occurred in 68 patients (8.3%). Among patients who were event-free at 3 months (n=812), clopidogrel was discontinued at 3 months in 661 patients and was continued for longer than 3 months in 151 patients. Discontinuation of clopidogrel at 3 months did not increase the primary outcome (HR 0.90; 95%CI, 0.09-9.02), death, MI, or any revascularization (HR 0.89; 95%CI, 0.48-1.67) after adjustment for the propensity score.
CONCLUSIONS: Three-month dual antiplatelet therapy seems to be feasible after ZES implantation in relatively low-risk patients.
Предметные рубрики MeSH
AgedAngioplasty, Balloon, CoronaryAspirinCardiovascular AgentsChi-Square DistributionClopidogrelCoronary AngiographyCoronary StenosisDisease-Free SurvivalDrug Administration ScheduleDrug Therapy, CombinationDrug-Eluting StentsFeasibility StudiesFemaleHumansKaplan-Meier EstimateLogistic ModelsMaleMiddle AgedMyocardial InfarctionPlatelet Aggregation InhibitorsPropensity ScoreProportional Hazards ModelsProspective StudiesProsthesis DesignRegistriesRepublic of KoreaRisk AssessmentRisk FactorsSirolimusThrombosisTiclopidineTime FactorsTreatment Outcome